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Table 1. Giant villous tumor of rectum in recent literature with size and malignant potential

From: Giant villous adenoma of rectum- what is the malignant potential and what is the optimal treatment? A case and review of literature

S no. Author Size Histopathology
1. Rickenbacher A, Bauerfeind P et al. [12] 1. 15 cm
2. –
3. 8 cm
-Low-grade dysplasia
-High-grade dysplasia
-Giant tubulovillous adenoma with a small focus of invasive carcinoma
2. Durán-Martínez M, Medina-Fernández FJ et al. [13] 10 × 8 × 4 cm Giant villous adenoma high-grade dysplasia
3. van der Pool AEM, de Graaf EJR et al. [14] 1. 12 cm
2. 24 cm2
3. 5–14 cm or 99 cm2
-Villous adenoma
-Villous adenoma with high-grade dysplasia and intramucosal carcinoma
-Villous adenoma with low-grade dysplasia
4. Agnes A, Novelli D et al. [15] 9 cm Villous adenoma with areas of intramucosal adenocarcinoma and high-grade dysplasia
5. Challis BG, Lim CT et al. [16] 10 cm Tubulovillous adenoma exhibiting moderate to low-grade dysplasia
6. Okano M, Okuyama M et al. [17] 10 cm  
7. Mois EI, Graur F et al. [18] 14 cm Low-grade dysplasia with focal high-grade dysplasia
8. Nakhla SG, Murakami TT et al. [19] 17 cm Large rectal villous adenoma coexistent with a poorly differentiated neuroendocrine tumor of the rectum
9. Kure K, Kawai M et al. [20] 12.7 × 11.5 cm Mostly tubulovillous adenoma, but partially moderately differentiated adenocarcinoma.
10. Das P, Vijay MK et al. [21] 8.5 × 6 × 4 cm Giant villous adenoma with low-grade dysplasia
11. Ohtsuka M, Hata T et al. [22]   Concurrent adenocarcinoma
12. Roriz-Silva R, Andrade AA et al. [23] 14 cm Villous adenoma with low-grade atypia
13. Aboul Hosn M, Abdel-Hafiez N et al. [24] 12 cm No evidence of invasive carcinoma
14. Barendse RM, van den Brandt S et al. [25] 9 cm Villous adenoma with focal high-grade dysplasia
15. Choi WH, Ryuk J et al. [26] 25 cm × 12 cm Well-differentiated adenocarcinomas arising in villotubular adenomas
16. Tuţă LA, Boşoteanu M et al. [27] 12 × 10 cm Well-differentiated adenocarcinoma arising within a villous adenoma.
17. Dagan A and Reissman P [28]. 31 cm Low- to high-grade dysplasia
18. Cubuk R, Tasali N et al. [29] 17 × 9 cm Villous adenoma without high-grade dysplasia
19. Koning GG, Rensma PL et al. [30] 15 × 8 Low-grade dysplasia
20. Nagri S, Eskaros S et al. [31] 8 × 5 × 4 cm Giant villous adenoma with high-grade dysplasia
21. Bains L, Lal P et al. (current case) 16 × 12 cm Giant villous adenoma of the rectum with moderate to severe dysplasia