Table 4 Correlation CD163+ TAMs in the tumour central area (TCA) or tumour-infiltrating front (TIF) with clinicopathological characteristics in HCC
Variable | CD163+/TCA | CD163−/TCA | p value |
|---|---|---|---|
No. of patients | 42 | 16 | |
Patient age, years | 0.177 | ||
≤ 60 | 13 (31.0%) | 8 (50.0%) | |
> 60 | 29 (69.9%) | 8 (50.0%) | |
Gender | 0.680 | ||
Female | 10 (76.2%) | 3 (18.8%) | |
Male | 32 (23.8%) | 13 (81.2%) | |
Local tumour recurrence | 0.398 | ||
Positive | 11 (26.2%) | 6 (37.5%) | |
Negative | 31 (73.8%) | 10 (62.5%) | |
Overall tumour recurrence | 0.320 | ||
Positive | 15 (35.7%) | 8 (50.0%) | |
Negative | 27 (64.3%) | 8 (50.0%) | |
Distant metastases | 0.469 | ||
Positive | 7 (16.7%) | 4 (25.0%) | |
Negative | 35 (83.3%) | 12 (75.0%) | |
Multiple tumour nodules | 0.016 | ||
Positive | 36 (85.7%) | 9 (56.3%) | |
Negative | 6 (14.3%) | 7 (43.8%) | |
Tumour size (mm) | 0.438 | ||
≤ 50 | 9 (21.4%) | 2 (12.5%) | |
> 50 | 33 (78.6%) | 14 (87.5%) | |
R status | 0.695 | ||
Positive | 35 (15.1%) | 2 (12.5%) | |
Negative | 7 (84.9%) | 14 (87.5%) | |
Angioinvasion | 0.311 | ||
Positive | 20 (47.6%) | 10 (62.5%) | |
Negative | 22 (52.4%) | 6 (37.5%) | |
Lymphangiosis carcinomatosa | 0.656 | ||
Positive | 13 (31.0%) | 4 (25.0%) | |
Negative | 29 (69.0%) | 12 (75.0%) | |
Histologic differentiation | 0.979 | ||
Well | 8 (19.0%) | 3 (18.8%) | |
Moderate/poor | 34 (81.0%) | 13 (81.3%) | |
Pathologic T stage | 0.501 | ||
T1/T2 | 22 (53.7%) | 7 (43.8%) | |
T3/T4 | 19 (46.3%) | 9 (56.3%) | |
Pathologic N stage | 0.470 | ||
Positive | 1 (02.4%) | 1 (06.3%) | |
Negative | 41 (97.6%) | 15 (93.7%) | |
No. of patients | 19 | 39 | |
Lymphangiosis carcinomatosa | 0.035 | ||
Positive | 9 (47.4%) | 8 (20.5%) | |
Negative | 10 (52.6%) | 31 (79.5%) |