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Table 3 Overall mortality and cancer-specific mortality in univariate and multivariable Cox regression analysis

From: Surgical resection of the primary tumor leads to prolonged survival in metastatic pancreatic neuroendocrine carcinoma

  Overall mortality in Cox regression Cancer-specific mortality in Cox regression
Univariable COX Multivariable cox Univariable cox Multivariable cox
HR (95%CI) P HR (95%CI) P HR (95%CI) P HR (95%CI) P
Sex
 Female(n = 145) Reference 0.325    Reference 0.41   
 Male(n = 205) 1.122 (0.892–1.413)     1.105 (0.871–1.402)    
Race
 White(n = 278) Reference .080    Reference .182   
 Black(n = 40) 1.357 (0.961–1.917) 0.083    1.333 (0.930–1.908) 0.117   
 Other(n = 32) 0.773 (0.515–1.162) 0.216    0.847 (0.563–1.274) 0.425   
Age
 < 65 years (n = 191) Reference 0.003    Reference 0.017   
 ≥ 65 years (n = 159) 1.413 (1.126–1.773)     1.333 (1.053–1.687)    
Grade
 III (n = 236) Reference 0.106    Reference 0.197   
 IV (n = 114) 1.223 (0.958–1.559)     1.181 (0.917–1.521)    
Tumor size
 < 2 cm (n = 4) Reference 0.062    Reference 0.48   
 2–4 cm (n = 96) 0.739 (0.270–2.025) 0.557    0.698 (0.254–1.915) 0.485   
 > 4 cm (n = 152) 0.645 (0.238–1.750) 0.389    0.615 (0.226–1.670) 0.34   
 Unknown (n = 98) 0.928 (0.340–2.531) 0.884       
Tumor location
 Head/overlapping/body (n = 205) Reference 0.001 Reference 0.03 Reference 0.002 Reference 0.045
 Tail (n = 80) 0.609 (0.456–0.815) 0.001 0.699(0.520–0.938) 0.017 0.600 (0.443–0.811) 0.001 0.685 (0.504–0.929) 0.015
 Unknown(n = 65) 1.177 (0.871–1.590) 0.289 1.094(0.809–1.482) 0.559 1.069 (0.777–1.470) 0.682 0.999 (0.725–1.376) 0.995
Lymph node metastases
 No (n = 14) Reference 0.001    Reference 0.003   
 Yes (n = 46) 0.936 (0.479–1.971) 0.936    1.151 (0.529–2.501) 0.723   
 Unknown(n = 290) 1.777 (0.941–3.353) 0.076    2.022 (0.997–4.103) 0.051   
Chemotherapy
 No (n = 129) Reference 0.003 Reference < 0.001 Reference 0.01 Reference < 0.001
 Yes (n = 221) 0.705 (0.558–0.890)   0.596(0.468–0.760)   0.726 (0.569–0.925)   0.624 (0.485–0.803)  
Year of diagnosis
 < 2010 (n = 212) Reference 0.062    Reference 0.102   
 ≥ 2010 (n = 138) 0.791 (0.619–1.012)     0.810 (0.629–1.043)    
Primary surgery
 No (n = 300) Reference < 0.001 Reference < 0.001 Reference < 0.001 Reference < 0.001
 Yes (n = 50) 0.479 (0.337–0.682)   0.427(0.294–0.621)   0.487 (0.337–0.703)   0.440 (0.298–0.648)