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Table 2 Association of clinical and pathological variables with survival (cancer-specific survival)

From: Surgical resection of the primary tumor leads to prolonged survival in metastatic pancreatic neuroendocrine carcinoma

Variable Group N Median (minimum–maximum) (month) 95% CI p
All   350 8 (1–138) 6.769–9.231  
Sex      0.309
Female 145 9 (1–112) 7.605–10.395  
Male 205 8 (1–138) 5.891–10.109  
Race      0.866
White 278 9 (1–138) 7.411–10.589  
Black 40 7 (1–36) 5.327–8.673  
Other 32 8 (1–92) 2.824–13.176  
Age      0.012
< 65y 191 9 (1–138) 7.592–10.408  
≥ 65y 159 6 (1–106) 4.208–7.792  
Grade      0.177
III 236 9 (1–138) 7.446–10.554  
IV 114 8 (1–76) 6.462–9.538  
Tumor size      0.24
< 2 cm 4 2 (2–28) Undefined*  
2–4 cm 96 9 (1–92) 6.880–11.120  
> 4 cm 152 9 (1–138) 7.346–10.654  
Tumor location      0.007
Head 146 8 (1–68) 6.399–9.601  
Overlapping 31 9 (1–112) 7.121–10.879  
Body 28 9 (1–106) 2.912–15.088  
Tail 80 11 (1–138) 7.952–14.048  
Lymph node metastases      0.729
No 14 9 (1–60) 0.000–37.636  
Yes 46 11 (1–138) 7.032–14.968  
Chemotherapy      0.007
No 129 4 (1–138) 2.763–5.237  
Yes 221 10 (1–112) 8.841–11.159  
Year of diagnosis      0.087
< 2010 212 8 (1–138) 6.698–9.302  
≥ 2010 138 10 (1–50) 7.705–12.295  
Primary site surgery      < 0.001
Surgery performed 50 12 (1–138) 2.079–21.921  
Surgery not performed 300 8 (1–112) 6.594–9.406  
Recommended but not performed 38 9 (1–76) 6.123–11.877  
Not recommended and not performed 262 7 (1–112) 5.523–8.477  
Site specific surgery      0.39
Local or partial pancreatectomy 24 26 (2–50) 11.541–40.459  
Total pancreatectomy 4 8 (4–138) 0.000–95.547  
Whipple 19 11 (1–68) 8.525–13.475  
Unknown 3 9 (4–26) 0.998–17.002  
Primary site surgery      0.216
Primary site only 25 10 (3–68) 3.129–16.871  
Primary site and distant site 25 19 (1–138) 1.487–36.513  
Distant site only 10 8 (1–112) 4.901–11.099  
  1. *Too small sample size and too different survival data of the patients might lead to the undefinition of the corresponding 95% CI