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Table 1 Patient clinicopathological characteristics in the FNA and SLNB groups

From: Higher axillary lymph node metastasis burden in breast cancer patients with positive preoperative node biopsy: may not be appropriate to receive sentinel lymph node biopsy in the post-ACOSOG Z0011 trial era

Characteristics

All patients

FNA

SLNB

P value

(N = 388)

N

(N = 202)

N (%)

(N = 186)

N (%)

Age [mean (range)] (year)

54.38 (31–84)

54.68 (31–84)

54.06 (31–83)

0.581

Tumor stage

0.021

 T1

138

61 (30.20)

77 (41.40)

 

 T2

250

141 (69.80)

109 (58.60)

 

Number of suspicious ALNs at US

< 0.001

 ≤ 1

207

37 (18.32)

170 (91.40)

 

 > 1

181

165 (81.68)

16 (8.60)

 

Pathological type

0.391

 Invasive ductal carcinoma

369

194 (96.04)

175 (94.09)

 

 Invasive lobular carcinoma

10

3 (1.49)

7 (3.76)

 

 Others

9

5 (2.48)

4 (2.15)

 

Histological grade

0.001

 I

15

4 (1.98)

11 (5.91)

 

 II

182

81 (40.10)

101 (54.30)

 

 III

191

117 (57.92)

74 (39.78)

 

LVI

< 0.001

 Negative

325

154 (76.24)

171 (91.94)

 

 Positive

63

48 (23.76)

15 (8.06)

 

Multifocality

0.485

 Unifocal

346

178 (88.12)

168 (90.32)

 

 Multifocal

42

24 (11.88)

18 (9.68)

 

ER status

0.002

 Negative

90

60 (29.70)

30 (16.13)

 

 Positive

298

142 (70.30)

156 (83.87)

 

PR status

0.007

 Negative

137

84 (41.58)

53 (28.49)

 

 Positive

251

118 (58.42)

133 (71.51)

 

HER2 status

0.002

 Negative

292

139 (68.81)

153 (82.26)

 

 Positive

96

63 (31.19)

33 (17.74)

 

Ki67 (%, mean)

< 0.001

 < 14%

114

41 (20.30)

73 (39.25)

 

 ≥ 14%

274

161 (79.70)

113 (60.75)

 

Molecular subtypes

0.003

 Luminal A

78

31 (15.35)

47 (25.27)

 

 Luminal B-HER2 negative

179

88 (43.56)

91 (48.92)

 

 Luminal B-HER2 positive

42

23 (11.39)

19 (10.22)

 

 HER2 positive

54

40 (19.80)

14 (7.53)

 

 Triple negative

35

20 (9.90)

15 (8.06)

 
  1. FNA fine-needle aspiration, SLNB sentinel lymph node biopsy, ALN axillary lymph node, US ultrasound, LVI lymph-vascular invasion, ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor type 2