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Table 2 Study characters of observational studies comparing TP and TR prostate biopsy

From: Transperineal versus transrectal prostate biopsy in the diagnosis of prostate cancer: a systematic review and meta-analysis

Study Age Study design Study population Patients PSA level Prostate volume Biopsy methods Covariates NOS score
TR group TP group TR group TP group TR group TP group
Emiliozzi et al., 2002, Italy [16] 68 Cohort study Patients with a PSA > 4 ng/ml between 2000.4 and 2001.5 107 8.2 NA Six transperineal cores plus six transrectal cores Self-control 9
Watanabe et al., 2005, Japan [32] 72.5 Cohort study Patients with clinically suspicious prostatic irregularities between 1995.1 and 2001.12 402 10.3 NA Combined 6-core transperineal and 6-core transrectal biopsies Self-control 9
Abdollah et al., 2010, Italy [19] 66.3 Cohort study Patients who underwent a rebiopsy between 2005.9 and 2008.6 140 140 9.7 10 65.4 62.3 Ultrasound-guided saturate prostate rebiopsy Age, PSA, PV, DRE, histologic findings on previous biopsy, the number of previous negative biopsy sets 8
Tian et al., 2014, China [31] 63 in TP group, 64 in TR group Cohort study Patients who underwent a biopsy between 2007.8 and 2012.7 175 137 1.91–112.52 1.45–108.27 59.5 62.4 Ultrasound-guided systematic prostate biopsy Age, PSA, DRE findings, PV 7
Yuan et al., 2014, China [13] 66 Cohort study Patients who underwent a biopsy between 2009.1 and 2014.1 59 97 21.2 19.7 33.7 35.8 Ultrasound-guided systematic prostate biopsy Age, PSA, PV 7
Pepe et al., 2016, Italy [18] 61 Cohort study Patients persistently suspicious of PCa between 2015.1 and 2016.1 200 8.6 NA mpMRI/TRUS fusion-targeted biopsy Self-control 9
Franco et al., 2017, Italy [17] 68 in TP group, 66 in TR group Cohort study Random patients that received a prostate biopsy between 2004 and 2014 108 111 7.8 6.9 NA Ultrasound-guided systematic sextant prostate biopsy Age, PSA, PSA ratio (F/T), DRE/TRUS findings, LUTS, BPH, biopsy cores, complications 7
  1. Abbreviations: TP transperineal, TR transrectal, PSA prostate-specific antigen, PV prostate volume, DRE digital rectal examination, PSA ratio F/T free PSA/total PCA, TRUS transrectal ultrasonography, LUTS lower urinary tract syndrome, BPH benign prostate hyperplasia, NA not available