|
Stratified
|
No. of studies
|
I2 (%)
|
HR (95% CI)
|
P value
|
|---|
|
Publication date (year)
|
|
1990–2000
|
4
|
0
|
0.17 (0, 0.34)
|
0.049
|
|
2001–2010
|
7
|
4.5
|
0.32 (0.19, 0.45)
|
< 0.0001
|
|
2011–2018
|
14
|
74.7
|
0.37 (0.25, 0.48)
|
< 0.0001
|
|
Study size (no. of patients)
|
|
< 500
|
9
|
63.1
|
0.42 (0.12, 0.71)
|
0.005
|
|
≥ 500
|
5
|
63.1
|
0.32 (0.23, 0.40)
|
< 0.0001
|
|
Region
|
|
Asia
|
4
|
0
|
0.31 (0.17, 0.45)
|
< 0.0001
|
|
Europe
|
12
|
56.9
|
0.29 (0.12, 0.46)
|
0.0001
|
|
America
|
5
|
88.7
|
0.40 (0.22, 0.57)
|
< 0.0001
|
|
Australia
|
3
|
0
|
0.29 (0.14, 0.44)
|
< 0.0001
|
|
Surgical type
|
|
Colorectal
|
18
|
48.6
|
0.31 (0.21, 0.41)
|
< 0.0001
|
|
Colonic
|
4
|
59.8
|
0.37 (0.23, 0.52)
|
< 0.0001
|
|
Rectal
|
2
|
63.8
|
0.28(− 0.21, − 0.77)
|
0.258
|
- No. number, HR hazard ratio, 95% CI 95% confidence interval
