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Table 2 Subgroup analyses for overall survival

From: Perioperative transfusion and the prognosis of colorectal cancer surgery: a systematic review and meta-analysis

Stratified No. of studies I2 (%) HR (95% CI) P value
Publication date (year)
 1990–2000 4 0 0.17 (0, 0.34) 0.049
 2001–2010 7 4.5 0.32 (0.19, 0.45) < 0.0001
 2011–2018 14 74.7 0.37 (0.25, 0.48) < 0.0001
Study size (no. of patients)
 < 500 9 63.1 0.42 (0.12, 0.71) 0.005
 ≥ 500 5 63.1 0.32 (0.23, 0.40) < 0.0001
Region
 Asia 4 0 0.31 (0.17, 0.45) < 0.0001
 Europe 12 56.9 0.29 (0.12, 0.46) 0.0001
 America 5 88.7 0.40 (0.22, 0.57) < 0.0001
 Australia 3 0 0.29 (0.14, 0.44) < 0.0001
Surgical type
 Colorectal 18 48.6 0.31 (0.21, 0.41) < 0.0001
 Colonic 4 59.8 0.37 (0.23, 0.52) < 0.0001
 Rectal 2 63.8 0.28(− 0.21, − 0.77) 0.258
  1. No. number, HR hazard ratio, 95% CI 95% confidence interval