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Table 3 Cox proportional hazards regression model multivariate analysis of the overall survival and breast cancer-specific survival in PR-negative cohort (forward: LR)

From: Characterization and prognosis of estrogen receptor-positive/progesterone receptor-negative male breast cancer: a population-based study

Variables OS BCSS
HR (95% CI) P value HR (95% CI) P value
Age at diagnosis
 ≤ 40 Reference  
 41–55 0.795 (0.365–1.733) 0.564
 56–70 0.812 (0.387–1.705) 0.582
 71–85 1.485 (0.695–3.173) 0.308
 > 85 2.834 (1.087–7.389) 0.033
Tumor size
 T1 Reference   Reference  
 T2 2.047 (1.443–2.902) < 0.001 2.177 (1.379–3.436) 0.001
 T3 5.696 (3.107–10.444) < 0.001 5.507 (2.749–11.034) < 0.001
 T4 2.565 (1.567–4.201) < 0.001 3.306 (1.825–5.989) < 0.001
 TX 0.536 (0.143–2.013) 0.356 1.296 (0.365–4.598) 0.688
Nodal status
 N0 Reference   Reference  
 N1 1.244 (0.864–1.791) 0.241 1.382 (0.869–2.199) 0.172
 N2 2.415 (1.544–3.779) < 0.001 2.379 (1.381–4.098) 0.002
 N3 2.264 (1.605–4.290) < 0.001 3.509 (1.993–6.181) < 0.001
 NX 2.954 (1.212–7.201) 0.017 3.073 (1.163–8.120) 0.024
Metastasis
 M0 Reference   Reference  
 M1 2.311 (1.452–3.677) < 0.001 3.200 (1.902–5.383) < 0.001
Surgery
 Done Reference   Reference  
 Not 2.143 (1.130–4.064) 0.020 3.120 (1.621–6.006) 0.001
 Unknown 2.629 (0.336–20.549) 0.357 1.683 (0.215–13.191) 0.62
Chemotherapy
 Yes Reference  
 No/unknown 1.492 (1.073–2.076) 0.017