Prognostic significance of sealed-off perforation in colon cancer: a prospective cohort study

Table 3 Risk factors for overall survival

	Hazard ratio	95% confidence interval	p value
Age (years old)	1.034	0.998–1.071	0.068
Sex (female)	0.839	0.350–2.012	0.694
BMI (kg/m²)	0.927	0.811–1.059	0.265
ASA class			0.011
1	1 (reference)	1 (reference)
2	0.465	0.16–1.320	0.150
3	3.503	0.977–12.563	0.054
Sealed-off perforation	0.759	0.162–3.554	0.727
Emergency operation	0.694	0.171–2.812	0.609
Palliative	2.340	0.520–10.532	0.268
Size (cm)	0.886	0.724–1.084	0.239
pT			0.025
3	1 (reference)	1 (reference)
4	3.480	1.174–10.318
pN			0.546
0	1 (reference)	1 (reference)
1	1.029	0.430–2.461	0.950
2	2.168	0.538–8.747	0.277
M1	4.766	1.432–15.860	0.011
Proximal margin (cm)	1.009	0.986–1.032	0.440
Distal margin (cm)	1.013	0.972–1.057	0.535
Venous invasion	1.013	0.246–2.199	0.583
Lymphatic invasion	1.541	0.614–3.862	0.357
Perineural invasion	2.225	0.754–6.569	0.148
Postoperative chemotherapy	0.562	0.188–1.677	0.302
Postoperative major complication†	3.931	1.009–15.319	0.049

BMI body mass index, ASA class American Society of Anesthesiologists classification
†Clavien-Dindo classification grade 3 or higher was defined as major complication

ISSN: 1477-7819