Prognostic significance of sealed-off perforation in colon cancer: a prospective cohort study

Table 2 Risk factors associated with cancer progression

	Hazard ratio	95% confidence interval	p value
Age (years old)	0.986	0.940–1.033	0.545
Sex (female)	2.039	0.677–6.141	0.205
ASA class			0.057
1	1 (reference)	1 (reference)
2	0.914	0.237–3.523	0.897
3	8.192	1.313–51.120	0.024
BMI (Kg/m²)	1.079	0.888–1.310	0.444
Sealed-off perforation	0.443	0.151–1.300	0.138
Emergency operation	0.082	0.008–0.864	0.037
Palliative	2.867	0.423–19.450	0.281
Size(cm)	1.483	1.074–2.046	0.017
pT			0.012
3	1 (reference)	1 (reference)
4	10.657	1.669–68.028
pN			0.697
1	0.603	0.170–2.139	0.434
2	0.606	0.096–3.816	0.594
M1	4.594	0.838–25.197	0.079
Proximal margin (cm)	1.041	1.002–1.082	0.038
Distal margin (cm)	0.949	0.887–1.016	0.134
Lymphatic invasion	1.535	0.514–4.568	0.444
Venous invasion	1.382	0.340–5.626	0.651
Perineural invasion	1.193	0.276–5.150	0.813
Postoperative chemotherapy	3.376	0.622–18.322	0.159
Postoperative major complication†	5.628	0.991–31.970	0.051

BMI body mass index, ASA class American Society of Anesthesiologists classification
†Clavien-Dindo classification grade 3 or higher was defined as major complication

ISSN: 1477-7819