Table 1 Circular RNAs in lung cancer

circFARSA

Upregulated in tissues and plasma

To promote cell migration and invasion

Sponge miR-330-5p and miR-326; upregulate fatty acid synthase

The area under the ROC curve was 0.71

[40]

CircRNA 100876

Upregulated in tissues

Unknown

Unknown

Higher expression level associated with lower overall survival

[26]

Hsa_circ_0013958

Upregulated in tissues, cells, and plasma

To promote cell proliferation and invasion and prevent apoptosis

Sponge miR-134; upregulate cyclin D1

The area under the ROC curve was 0.815

[27]

Circular RNA-ITCH

Downregulated in tissues

To inhibit cell proliferation

Sponge miR-7 and miR-214; upregulate ITCH

Unknown

[21]

Hsa_circ_0043256

Upregulated in NSCLC cells in response to CA treatment

To inhibit cell proliferation and induce apoptosis

Sponge miR-1252; upregulate ITCH; inhibits the Wnt/β-catenin pathway

Unknown

[47]

Circ-BANP

Upregulated in tissues

To promote cell proliferation, migration, and invasion

Sponge miR-503; upregulate LARP1 expression

Higher expression level associated with lower overall survival

[36]

Circ_0067934

Upregulated in NSCLC tissues and cell lines

To promote cell proliferation, migration, and invasion

Modulate the expression levels of markers of epithelial-to-mesenchymal transition

Higher expression level associated with lower overall survival

[43]

CircRNF13

Downregulated in tissues

To inhibit cell invasion and metastasis

Sponge miR-93-5p

Unknown

[8]

CircMAN2B2

Upregulated in tissues and cell lines

To promote cell proliferation and invasion

Sponge miR-1275; upregulate FOXK1 expression

Unknown

[34]

F-circEA

Existence in plasma and H2228 cells

To promote cell migration and invasion

Unknown

F-circEA was specifically existed in EML4-ALK-positive NSCLC

[39]

Hsa_circRNA_103809

Upregulated in tissues and cell lines

To promote cell proliferation and invasion

Sponge miR-4302; upregulate the expression of ZNF121; enhance MYC protein level

Higher expression level associated with lower overall survival

[29]

CircUBAP2

Upregulated in tissues

To promote cell proliferation, invasion and prevent apoptosis

Upregulate CDK6,cyclin D1, c-IAP1, Bcl-2, Survivin, FAK, Rac1, MMP2, JNK and ERK1/2; downregulate p27 and Bax; sponge miR-339-5p, miR-96-3p and miR-135b-3p

Unknown

[28]

Hsa_circ_0000064

Upregulated in tissues and cell lines

To promote cell proliferation and cycle progression and prevent apoptosis

Upregulate caspase-3, caspase-9, bax, p21, CDK6, cyclin D1, MMP-2, and MMP-9; downregulate bcl-2

Unknown

[42]

Hsa_circ_0046264

Downregulated in tissues and cell lines

To inhibit proliferation and invasion, to promote cell apoptosis

Sponge miR-1245; upregulate BRCA2

Lower expression level associated with worse prognosis outcome

[37]

Hsa_circ_0079530

Upregulated in tissues and cell lines

To promote cell proliferation, migration, invasion and cycle progression

Unknown

The area under the ROC curve was 0.756

[41]

CircRNA-FOXO3

Downregulated in tissues and cell lines

To inhibit cell proliferation, migration, and invasion

Sponge miR-155; upregulate FOXO3

The area under the ROC curve was 0.782

[33]

Hsa_circ_0012673

Upregulated in tissues

To promote cell proliferation

Sponge miR-22; upregulate ErbB3

Unknown

[32]

Hsa_circRNA_103827

Upregulated in tissues

Unknown

Unknown

Higher expression level associated with shorter overall survival

[45]

Hsa_circRNA_000122

Downregulated in tissues

Unknown

Unknown

Lower expression level associated with shorter overall survival

[45]

Hsa_circ_0014130

Upregulated in tissues

Unknown

Unknown

The area under the ROC curve was 0.878

[22]

Hsa_circ_0007385

Upregulated in tissues and cells

To promote cell proliferation, migration, and invasion

Sponge miR-181

Unknown

[35]

Circ0006916

Downregulated in 16HBE-T,A549 and H460 cell lines

To inhibit cell proliferation and cycle progression

Sponge miR-522-3p; upregulate PHLPP1

Unknown

[30]

CircPRKCI

Upregulated in tissues

To promote cell proliferation and migration

Sponge miR-545 and miR-589; upregulate E2F7 expression

Higher expression level associated with shorter overall survival

[31]

Circ_001569

Upregulated in tissues

Promote cell proliferation

Promote the Wnt/β-catenin pathway

Higher expression level associated with poorer survival outcome

[44]