Skip to main content

Table 1 Circular RNAs in lung cancer

From: Progress in research on the role of circular RNAs in lung cancer

CircRNA Expression level Function Mechanism Diagnostic and prognostic value Reference
circFARSA Upregulated in tissues and plasma To promote cell migration and invasion Sponge miR-330-5p and miR-326; upregulate fatty acid synthase The area under the ROC curve was 0.71 [40]
CircRNA 100876 Upregulated in tissues Unknown Unknown Higher expression level associated with lower overall survival [26]
Hsa_circ_0013958 Upregulated in tissues, cells, and plasma To promote cell proliferation and invasion and prevent apoptosis Sponge miR-134; upregulate cyclin D1 The area under the ROC curve was 0.815 [27]
Circular RNA-ITCH Downregulated in tissues To inhibit cell proliferation Sponge miR-7 and miR-214; upregulate ITCH Unknown [21]
Hsa_circ_0043256 Upregulated in NSCLC cells in response to CA treatment To inhibit cell proliferation and induce apoptosis Sponge miR-1252; upregulate ITCH; inhibits the Wnt/β-catenin pathway Unknown [47]
Circ-BANP Upregulated in tissues To promote cell proliferation, migration, and invasion Sponge miR-503; upregulate LARP1 expression Higher expression level associated with lower overall survival [36]
Circ_0067934 Upregulated in NSCLC tissues and cell lines To promote cell proliferation, migration, and invasion Modulate the expression levels of markers of epithelial-to-mesenchymal transition Higher expression level associated with lower overall survival [43]
CircRNF13 Downregulated in tissues To inhibit cell invasion and metastasis Sponge miR-93-5p Unknown [8]
CircMAN2B2 Upregulated in tissues and cell lines To promote cell proliferation and invasion Sponge miR-1275; upregulate FOXK1 expression Unknown [34]
F-circEA Existence in plasma and H2228 cells To promote cell migration and invasion Unknown F-circEA was specifically existed in EML4-ALK-positive NSCLC [39]
Hsa_circRNA_103809 Upregulated in tissues and cell lines To promote cell proliferation and invasion Sponge miR-4302; upregulate the expression of ZNF121; enhance MYC protein level Higher expression level associated with lower overall survival [29]
CircUBAP2 Upregulated in tissues To promote cell proliferation, invasion and prevent apoptosis Upregulate CDK6,cyclin D1, c-IAP1, Bcl-2, Survivin, FAK, Rac1, MMP2, JNK and ERK1/2; downregulate p27 and Bax; sponge miR-339-5p, miR-96-3p and miR-135b-3p Unknown [28]
Hsa_circ_0000064 Upregulated in tissues and cell lines To promote cell proliferation and cycle progression and prevent apoptosis Upregulate caspase-3, caspase-9, bax, p21, CDK6, cyclin D1, MMP-2, and MMP-9; downregulate bcl-2 Unknown [42]
Hsa_circ_0046264 Downregulated in tissues and cell lines To inhibit proliferation and invasion, to promote cell apoptosis Sponge miR-1245; upregulate BRCA2 Lower expression level associated with worse prognosis outcome [37]
Hsa_circ_0079530 Upregulated in tissues and cell lines To promote cell proliferation, migration, invasion and cycle progression Unknown The area under the ROC curve was 0.756 [41]
CircRNA-FOXO3 Downregulated in tissues and cell lines To inhibit cell proliferation, migration, and invasion Sponge miR-155; upregulate FOXO3 The area under the ROC curve was 0.782 [33]
Hsa_circ_0012673 Upregulated in tissues To promote cell proliferation Sponge miR-22; upregulate ErbB3 Unknown [32]
Hsa_circRNA_103827 Upregulated in tissues Unknown Unknown Higher expression level associated with shorter overall survival [45]
Hsa_circRNA_000122 Downregulated in tissues Unknown Unknown Lower expression level associated with shorter overall survival [45]
Hsa_circ_0014130 Upregulated in tissues Unknown Unknown The area under the ROC curve was 0.878 [22]
Hsa_circ_0007385 Upregulated in tissues and cells To promote cell proliferation, migration, and invasion Sponge miR-181 Unknown [35]
Circ0006916 Downregulated in 16HBE-T,A549 and H460 cell lines To inhibit cell proliferation and cycle progression Sponge miR-522-3p; upregulate PHLPP1 Unknown [30]
CircPRKCI Upregulated in tissues To promote cell proliferation and migration Sponge miR-545 and miR-589; upregulate E2F7 expression Higher expression level associated with shorter overall survival [31]
Circ_001569 Upregulated in tissues Promote cell proliferation Promote the Wnt/β-catenin pathway Higher expression level associated with poorer survival outcome [44]