From: Progress in research on the role of circular RNAs in lung cancer
CircRNA | Expression level | Function | Mechanism | Diagnostic and prognostic value | Reference |
---|---|---|---|---|---|
circFARSA | Upregulated in tissues and plasma | To promote cell migration and invasion | Sponge miR-330-5p and miR-326; upregulate fatty acid synthase | The area under the ROC curve was 0.71 | [40] |
CircRNA 100876 | Upregulated in tissues | Unknown | Unknown | Higher expression level associated with lower overall survival | [26] |
Hsa_circ_0013958 | Upregulated in tissues, cells, and plasma | To promote cell proliferation and invasion and prevent apoptosis | Sponge miR-134; upregulate cyclin D1 | The area under the ROC curve was 0.815 | [27] |
Circular RNA-ITCH | Downregulated in tissues | To inhibit cell proliferation | Sponge miR-7 and miR-214; upregulate ITCH | Unknown | [21] |
Hsa_circ_0043256 | Upregulated in NSCLC cells in response to CA treatment | To inhibit cell proliferation and induce apoptosis | Sponge miR-1252; upregulate ITCH; inhibits the Wnt/β-catenin pathway | Unknown | [47] |
Circ-BANP | Upregulated in tissues | To promote cell proliferation, migration, and invasion | Sponge miR-503; upregulate LARP1 expression | Higher expression level associated with lower overall survival | [36] |
Circ_0067934 | Upregulated in NSCLC tissues and cell lines | To promote cell proliferation, migration, and invasion | Modulate the expression levels of markers of epithelial-to-mesenchymal transition | Higher expression level associated with lower overall survival | [43] |
CircRNF13 | Downregulated in tissues | To inhibit cell invasion and metastasis | Sponge miR-93-5p | Unknown | [8] |
CircMAN2B2 | Upregulated in tissues and cell lines | To promote cell proliferation and invasion | Sponge miR-1275; upregulate FOXK1 expression | Unknown | [34] |
F-circEA | Existence in plasma and H2228 cells | To promote cell migration and invasion | Unknown | F-circEA was specifically existed in EML4-ALK-positive NSCLC | [39] |
Hsa_circRNA_103809 | Upregulated in tissues and cell lines | To promote cell proliferation and invasion | Sponge miR-4302; upregulate the expression of ZNF121; enhance MYC protein level | Higher expression level associated with lower overall survival | [29] |
CircUBAP2 | Upregulated in tissues | To promote cell proliferation, invasion and prevent apoptosis | Upregulate CDK6,cyclin D1, c-IAP1, Bcl-2, Survivin, FAK, Rac1, MMP2, JNK and ERK1/2; downregulate p27 and Bax; sponge miR-339-5p, miR-96-3p and miR-135b-3p | Unknown | [28] |
Hsa_circ_0000064 | Upregulated in tissues and cell lines | To promote cell proliferation and cycle progression and prevent apoptosis | Upregulate caspase-3, caspase-9, bax, p21, CDK6, cyclin D1, MMP-2, and MMP-9; downregulate bcl-2 | Unknown | [42] |
Hsa_circ_0046264 | Downregulated in tissues and cell lines | To inhibit proliferation and invasion, to promote cell apoptosis | Sponge miR-1245; upregulate BRCA2 | Lower expression level associated with worse prognosis outcome | [37] |
Hsa_circ_0079530 | Upregulated in tissues and cell lines | To promote cell proliferation, migration, invasion and cycle progression | Unknown | The area under the ROC curve was 0.756 | [41] |
CircRNA-FOXO3 | Downregulated in tissues and cell lines | To inhibit cell proliferation, migration, and invasion | Sponge miR-155; upregulate FOXO3 | The area under the ROC curve was 0.782 | [33] |
Hsa_circ_0012673 | Upregulated in tissues | To promote cell proliferation | Sponge miR-22; upregulate ErbB3 | Unknown | [32] |
Hsa_circRNA_103827 | Upregulated in tissues | Unknown | Unknown | Higher expression level associated with shorter overall survival | [45] |
Hsa_circRNA_000122 | Downregulated in tissues | Unknown | Unknown | Lower expression level associated with shorter overall survival | [45] |
Hsa_circ_0014130 | Upregulated in tissues | Unknown | Unknown | The area under the ROC curve was 0.878 | [22] |
Hsa_circ_0007385 | Upregulated in tissues and cells | To promote cell proliferation, migration, and invasion | Sponge miR-181 | Unknown | [35] |
Circ0006916 | Downregulated in 16HBE-T,A549 and H460 cell lines | To inhibit cell proliferation and cycle progression | Sponge miR-522-3p; upregulate PHLPP1 | Unknown | [30] |
CircPRKCI | Upregulated in tissues | To promote cell proliferation and migration | Sponge miR-545 and miR-589; upregulate E2F7 expression | Higher expression level associated with shorter overall survival | [31] |
Circ_001569 | Upregulated in tissues | Promote cell proliferation | Promote the Wnt/β-catenin pathway | Higher expression level associated with poorer survival outcome | [44] |