Table 2 Comparison of clinicopathological characteristics of breast cancer according to timing of recurrence as early and late recurrence*
Variables | Rec < 5 years (n = 561) | Rec > 5 years (n = 151) | No rec > 10 years (n = 561) | p value |
|---|---|---|---|---|
Age, years | 54.25 ± 11.76 | 59.18 ± 9.67 | 60.26 ± 9.86 | < 0.001 |
Number of pregnancies | 1.29 ± 2.29 | 1.39 ± 2.25 | 1.92 ± 2.43 | < 0.001 |
Number of abortions | 0.22 ± 0.703 | 0.20 ± 0.62 | 0.28 ± 0.66 | 0.287 |
Number of children | 1.24 ± 2.176 | 1.35 ± 2.20 | 1.83 ± 2.32 | < 0.001 |
Breast feeding duration, months | 20.12 ± 39.71 | 20.64 ± 35.56 | 29.43 ± 47.19 | 0.001 |
Tumor size, cm | 3.21 ± 1.80 | 0.50 ± 1.46 | 2.87 ± 1.53 | < 0.001 |
Duration of sports activity, h/week | 0.57 ± 2.30 | 0.05 ± 1.46 | 0.79 ± 1.87 | < 0.001 |
Breast side involvement, no. (%) | ||||
Left | 311 (56) | 68 (45.6) | 285 (50.8) | 0.040 |
Right | 244 (44) | 81 (54.4) | 276 (49.2) | |
Hormone replacement therapy, no. (%) | ||||
Yes | 3 (1.4) | 2 (3.3) | 5 (0.9) | 0.611 |
No | 204 (98.6) | 58 (96.7) | 556 (99.1) | |
Diabetes, no. (%) | ||||
Yes | 35 (6.2) | 20 (13.2) | 75 (13.4) | < 0.001 |
No | 526 (93.8) | 131 (86.8) | 486 (86.6) | |
History of breast disease, no. (%) | ||||
Yes | 13 (2.3) | 1 (0.7) | 9 (1.6) | 0.355 |
No | 548 (97.7) | 150 (99.3) | 552 (98.4) | |
History of breast operation, no. (%) | ||||
Yes | 2 (0.4) | 3 (2) | 7 (1.2) | 0.112 |
No | 559 (99.6) | 148 (98) | 554 (98.8) | |
Family Hx of breast cancer, no. (%) | ||||
Yes | 57 (10.2) | 16 (10.6) | 76 (13.5) | 0.190 |
No | 504 (89.8) | 135 (89.4) | 485 (86.5) | |
Family Hx of other cancer, no. (%) | ||||
Yes | 82 (14.6) | 39 (25.8) | 124 (22.1) | 0.001 |
No | 479 (85.4) | 112 (74.2) | 437 (77.9) | |
Smoking, no. (%) | ||||
Yes | 5 (0.9) | 0 | 2 (0.4) | 0.299 |
No | 556 (99.1) | 151 (100) | 559 (99.6) | |
Waterpipe use, no. (%) | ||||
Yes | 22 (3.9) | 4 (2.6) | 26 (4.6) | 0.531 |
No | 539 (96.1) | 147 (97.4) | 535 (95.4) | |
Sports activity, no. (%) | ||||
Yes | 68 (12.1) | 19 (12.6) | 104 (18.5) | 0.007 |
No | 493 (87.9) | 132 (87.4) | 457 (81.5) | |
Regular sports activity, no. (%) | ||||
Yes | 24 (4.3) | 8 (5.3) | 47 (8.4) | 0.015 |
No | 537 (95.7) | 143 (94.7) | 514 (91.6) | |
Lymph node management, no. (%) | ||||
SLNB | 48 (8.6) | 6 (4) | 506 (90.2) | < 0.001 |
AND | 438 (78.1) | 126 (83.4) | 13 (2.3) | |
Both | 34 (6.1) | 3 (2) | 3 (0.5) | |
None | 41 (7.3) | 16 (10.6) | 39 (7) | |
In situ component, no. (%) | ||||
Yes | 310 (69.7) | 55 (69.6) | 191 (34) | 0.578 |
No | 135 (30.3) | 24 (30.4) | 370 (66) | |
Tumor necrosis, no. (%) | ||||
Yes | 264 (58.3) | 33 (39.8) | 132 (23.5) | < 0.001 |
No | 189 (41.7) | 50 (60.2) | 429 (76.5) | |
Chemotherapy before surgery, no. (%) | ||||
Yes | 53 (9.4) | 7 (4.6) | 49 (8.7) | 0.169 |
No | 508 (90.6) | 144 (95.4) | 512 (91.3) | |
Chemotherapy after surgery, no. (%) | ||||
Yes | 547 (97.5) | 148 (98) | 541 (96.4) | 0.438 |
No | 14 (2.5) | 3 (2) | 20 (3.6) | |
Radiotherapy, no. (%) | ||||
Mastectomy with radiotherapy | 166 (29.6) | 139 (92.1) | 265 (47.2) | < 0.001 |
Mastectomy without radiotherapy | 2 (0.4) | 0 | 123 (21.9) | |
BCS with radiotherapy | 380 (67.7) | 10 (6.6) | 172 (30.7) | |
BCS without radiotherapy | 13 (2.3) | 2 (1.3) | 1 (0.2) | |
Hormone therapy, no. (%) | ||||
Yes | 303 (76.7) | 101 (88.6) | 365 (86.3) | < 0.001 |
No | 92 (23.3) | 13 (11.4) | 58 (13.7) | |
Stage, no. (%) | ||||
0 | 129 (23) | 12 (7.9) | 116 (20.7) | < 0.001 |
1 | 278 (49.6) | 84 (55.6) | 302 (53.8) | |
2 | 134 (23.9) | 48 (31.8) | 126 (22.5) | |
3 and 4 | 20 (3.6) | 7 (4.6) | 17 (3) | |
Grade, no. (%) | ||||
1, 2 | 448 (79.9) | 137 (90.7) | 511 (91.1) | < 0.001 |
3 | 113 (13.9) | 14 (9.3) | 50 (8.9) | |