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Table 2 Association of several variables with risk of papillary thyroid carcinoma in the case-control study

From: Assessment of thyroid cancer risk in more than 334,000 patients with inflammatory bowel disease: a case-control study and a meta-analysis

Group

Subgroup

PTCa

Total

Univariate

OR (95%CI)a,b

Univariate

P value c

Multivariate

OR (95%CI)b

Multivariate

P valuec

Gender

Female

9

1492

Reference

 

Reference

 

Male

5

1292

0.64 (0.20~1.92)

0.425

0.65 (0.21~1.93)

0.424

Age (years)

< 36.9 years

6

1428

Reference

 

Reference

 

≥ 36.9 years

8

1356

1.41 (0.49~4.06)

0.529

1.42 (0.49~4.07)

0.528

BMI (kg/m2)a

< 22.8 kg/m2

5

1408

Reference

 

Reference

 

≥ 22.8 kg/m2

9

1376

1.85 (0.61~5.54)

0.272

1.86 (0.62~5.54)

0.271

History of smoking

Absent

5

1884

Reference

 

Reference

 

Present

9

900

3.80 (1.27~11.36)

0.017

3.81 (1.27~11.37)

0.016

History of drinking

Absent

7

1979

Reference

 

Reference

 

Present

7

805

2.47 (0.86~7.07)

0.092

2.48 (0.87~7.08)

0.092

History of ISIa

Absent

4

1322

Reference

 

Reference

 

Present

10

1462

2.26 (0.72~7.24)

0.167

2.27 (0.72~7.25)

0.166

History of REa

Absent

9

2519

Reference

 

Reference

 

Present

5

265

5.36 (1.78~16.12)

0.003

5.37 (1.78~16.13)

0.003

History of BTNa

Absent

1

1150

Reference

 

Reference

 

Present

13

1634

9.21 (1.20~70.53)

0.032

9.22 (1.21~70.54)

0.031

Family history of TCa

Absent

8

2627

Reference

 

Reference

 

Present

6

157

13.01 (4.47~37.96)

< 0.001

13.02 (4.47~37.97)

< 0.001

History of IBDa

Control

3

1392

Reference

 

Reference

 

IBD

11

1392

3.69 (1.04~13.25)

0.045

3.70 (1.04~13.26)

0.044

History of CDa

Control

3

1392

Reference

 

Reference

 

CD

2

370

2.52 (0.43~15.12)

0.313

2.53 (0.43~15.13)

0.313

History of UCa

Control

3

1392

Reference

 

Reference

 

UC

9

1022

4.11 (1.12~15.23)

0.034

4.12 (1.12~15.24)

0.033

  1. aBMI body mass index, ISI iodized salt intaking, RE radiation exposure, BTN benign thyroid nodule, IBD inflammatory bowel disease, UC ulcerative colitis, CD Crohn’s disease, TC thyroid cancer, PTC papillary thyroid carcinoma, OR odds ratio, CI confidence interval
  2. bUnivariate analysis was not adjusted by potential confounding factor. Multivariate analysis was adjusted by age, gender, body mass index, smoking, drinking alcohol, iodized salt intaking, radiation exposure, benign thyroid nodule, and family history of thyroid cancer
  3. cBonferroni correction was adopted for multiple analyses, and Bonferroni corrected P value was 0.004 (0.05/12 variables). If a P value was less than 0.004, it was statistically significant
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World Journal of Surgical Oncology

ISSN: 1477-7819

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