Skip to main content

Table 1 Gene ontology analysis of the DEGs

From: Prediction of key genes and pathways involved in trastuzumab-resistant gastric cancer

Category Term/gene function Gene count % p value FDR
GOTERM_BP_FAT GO:0060429~epithelium development 112 13.25444 1.53E−17 3.01E−14
GOTERM_BP_FAT GO:0007166~cell surface receptor signaling pathway 207 24.49704 2.44E−16 4.33E−13
GOTERM_BP_FAT GO:0040011~locomotion 134 15.85799 4.27E−14 8.38E−11
GOTERM_BP_FAT GO:2000026~regulation of multicellular organismal development 145 17.15976 6.52E−14 1.28E−10
GOTERM_BP_FAT GO:0009887~organ morphogenesis 99 11.71598 9.11E−14 1.79E−10
GOTERM_CC_FAT GO:0031988~membrane-bounded vesicle 255 30.17751 2.34E−13 3.49E−10
GOTERM_CC_FAT GO:0044421~extracellular region part 266 31.47929 1.57E−12 2.34E−09
GOTERM_CC_FAT GO:1903561~extracellular vesicle 206 24.3787 1.08E−11 1.61E−08
GOTERM_CC_FAT GO:0043230~extracellular organelle 206 24.3787 1.11E−11 1.65E−08
GOTERM_CC_FAT GO:0070062~extracellular exosome 204 24.14201 2.24E−11 3.34E−08
GOTERM_MF_FAT GO:0050839~cell adhesion molecule binding 53 6.272189 1.39E−09 2.27E−06
GOTERM_MF_FAT GO:0001948~glycoprotein binding 20 2.366864 1.71E−07 2.78E−04
GOTERM_MF_FAT GO:0019838~growth factor binding 21 2.485207 1.31E−06 0.002133
GOTERM_MF_FAT GO:0098631~protein binding involved in cell adhesion 34 4.023669 4.03E−06 0.006547
GOTERM_MF_FAT GO:0000982~transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding 36 4.260355 7.11E−06 0.011559
  1. As a total of 193 biological processes (BP), 23 cellular components (CC), nine molecular functions (MF) enriched in gene ontology (GO), only the top five in each term according to the false discovery rate (FDR) value were illustrated
  2. DEGs differentially expressed genes