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Table 1 Gene ontology analysis of the DEGs

From: Prediction of key genes and pathways involved in trastuzumab-resistant gastric cancer

Category

Term/gene function

Gene count

%

p value

FDR

GOTERM_BP_FAT

GO:0060429~epithelium development

112

13.25444

1.53E−17

3.01E−14

GOTERM_BP_FAT

GO:0007166~cell surface receptor signaling pathway

207

24.49704

2.44E−16

4.33E−13

GOTERM_BP_FAT

GO:0040011~locomotion

134

15.85799

4.27E−14

8.38E−11

GOTERM_BP_FAT

GO:2000026~regulation of multicellular organismal development

145

17.15976

6.52E−14

1.28E−10

GOTERM_BP_FAT

GO:0009887~organ morphogenesis

99

11.71598

9.11E−14

1.79E−10

GOTERM_CC_FAT

GO:0031988~membrane-bounded vesicle

255

30.17751

2.34E−13

3.49E−10

GOTERM_CC_FAT

GO:0044421~extracellular region part

266

31.47929

1.57E−12

2.34E−09

GOTERM_CC_FAT

GO:1903561~extracellular vesicle

206

24.3787

1.08E−11

1.61E−08

GOTERM_CC_FAT

GO:0043230~extracellular organelle

206

24.3787

1.11E−11

1.65E−08

GOTERM_CC_FAT

GO:0070062~extracellular exosome

204

24.14201

2.24E−11

3.34E−08

GOTERM_MF_FAT

GO:0050839~cell adhesion molecule binding

53

6.272189

1.39E−09

2.27E−06

GOTERM_MF_FAT

GO:0001948~glycoprotein binding

20

2.366864

1.71E−07

2.78E−04

GOTERM_MF_FAT

GO:0019838~growth factor binding

21

2.485207

1.31E−06

0.002133

GOTERM_MF_FAT

GO:0098631~protein binding involved in cell adhesion

34

4.023669

4.03E−06

0.006547

GOTERM_MF_FAT

GO:0000982~transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding

36

4.260355

7.11E−06

0.011559

  1. As a total of 193 biological processes (BP), 23 cellular components (CC), nine molecular functions (MF) enriched in gene ontology (GO), only the top five in each term according to the false discovery rate (FDR) value were illustrated
  2. DEGs differentially expressed genes