Fig. 1
From: Review of the possible association between thyroid and breast carcinoma
Regulation and expression of the NIS gene in breast cancer. In breast cancer cells, the NIS protein is predominantly expressed in the intracellular space, whereas the protein is located on the basolateral membrane in lactating mammary glands. Mislocalization of the NIS protein may lead to a disparity between the NIS expression level and observed radioiodide uptake