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Table 1 Baseline and clinical characteristics among age groups*

From: Do site and type of metastasis in breast cancer show a changing pattern with increased age? A cross comparison of clinicopathological characteristics between age groups

Variables Group 1 (n = 564)† Group 2 (n = 4519) Group 3 (n = 670) p value
Tumor size—cm   2.70 ± 1.44 2.72 ± 1.37 2.73 ± 1.40 0.90
Breast side—no. (%) Left 297 (52.7) 2339 (51.8) 357 (53.3) 0.727
Right 267 (47.3) 2180 (48.2) 313 (46.7)
Pathology subtype—no. (%) Insitu 17 (3.1)a 129 (3)a 16 (2.5)a < 0.001
Mucinous 2 (0.4)a 40 (0.9)a 14 (2.2)b
Medullary 25 (4.6)a 172 (4)a 17 (2.7)a
Papillary 2 (0.4)b 8 (0.2)b 6 (0.9)a
Invasive ductal 448 (82.4)b 3650 (83.8)b 512 (80.4)a
Invasive lobular 4 (0.7)a 151 (3.5)b 34 (5.3)c
Mixed pattern 25 (4.6)a 131 (3)b 13 (2)b
Other 19 (3.5)a 72 (1.7)b 25 (3.9)a
Insitu component—no. (%) Yes 138 (31.1) 1058 (31.1) 161 (34.5) 0.326
No 306 (68.9) 2339 (68.9) 305 (65.5)
Tumor necrosis—no. (%) Yes 169 (36.4)a 1536 (44.6)b 232 (48.9)b < 0.001
No 295 (63.6)a 1908 (55.4)b 242 (51.1)b
Invasion—no. (%) Lymphatic 49 (9.8)a 540 (13.7)b 87 (14.9)b 0.002
Vascular 5 (1)a 80 (2)b 16 (2.7)b
Preneural 36 (7.2)a 298 (7.6)a 54 (9.3)a
Lymphatic & preneural 7 (1.4)a 109 (2.8)a 25 (4.3)b
Preneural & vascular 2 (0.4)a 37 (0.9)a 8 (1.4)a
Lymphatic & vascular 108 (21.6)a 747 (19)a 87 (14.9)b
None 192 (38.5)a 1485 (37.8)a 212 (36.4)a
ER receptor—no. (%) Positive 363 (68.6)a 3162 (74.4)b 475 (76.9)b 0.001
Negative 165(31.2)a 1082 (25.5)b 143 (23.1)b
PR receptor—no. (%) Positive 335 (63.4)a 2906 (68.6)b 426 (69.7)b 0.102
Negative 193 (36.3)a 1324 (31.2)b 184 (30.1)b
HER2 receptor—no. (%) Positive 151 (29.9%)a 942 (27.2%)a 84 (19.2%)b < 0.001
Negative 354 (70.1%)a 2521 (72.8%)a 353 (80.8%)b
Stage—no. (%) 0 17 (3.5)a 129 (3.3)a 16 (3.1)a 0.016
1 101 (20.9)a 895 (22.9)a 122 (23.5)a
2 208 (43.1)a 1824 (46.7)a 272 (52.4)b
3 150 (31.1)a 1001 (25.6)b 102 (19.7)c
4 7 (1.4)a 59 (1.5)a 7 (1.3)a
Grade—no. (%) 1 70 (15.9)a 759 (21.9)b 139 (28)c 0.001
2 250 (56.7)a 1991 (57.4)a 275 (55.4)a
3 121 (27.4)a 713 (20.6)b 82 (16.5)c
Grade of nucleus—no. (%) 1 26 (12)a 215 (18.3)b 40 (29.9)c < 0.001
2 97 (44.9)a 553 (47.2)a 57 (42.5)a
3 93 (43.1)a 404 (34.5)b 37 (27.6)b
  1. ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor 2
  2. *Plus minus values are means and standard deviations unless stated otherwise. Superscript alphabets represent the results of the post-hoc test, and accordingly, different alphabets show significant difference between groups. “a” is statistically different from “b” and “c”, “b” is statistically different from “a” and “c”, and “c” is statistically different from “a” and “b”
  3. †Age group 1 represent those younger than 30 years old, age group 2 represents those between 30 and 60 years old, and age group 3 represents those older than 60 years old