Table 2 Intensity of HIF-1alpha and CAIX compared to clinicopathological variables in pancreatic ductal adenocarcinoma. Statistically significant p values are italicized
From: Weak HIF-1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma
Variable | n/N | Nuclear HIF-1alpha intensity, n | n/N | Membranous CAIX intensity, n | ||||
|---|---|---|---|---|---|---|---|---|
Weak | Strong | p | Weak | Strong | p | |||
pT | ||||||||
T1 | 4/64 | 1 | 3 | 0.439 | 4/65 | 4 | 0 | 0.533 |
T2 | 22/64 | 11 | 11 | 22/65 | 15 | 7 | ||
T3 | 32/64 | 20 | 12 | 33/65 | 23 | 10 | ||
T4 | 6/64 | 4 | 2 | 6/65 | 5 | 1 | ||
Lymph nodes | ||||||||
Positive | 31/64 | 16 | 15 | 0.556 | 32/65 | 23 | 9 | 0.823 |
Negative | 32/64 | 19 | 13 | * | 32/65 | 23 | 9 | * |
Stage | ||||||||
I | 18/63 | 7 | 11 | 0.236 | 18/64 | 13 | 5 | 0.794 |
II | 39/63 | 24 | 15 | * | 40/64 | 28 | 12 | * |
III–IV | 6/63 | 4 | 2 | 6/64 | 5 | 1 | ||
Tumor grade | ||||||||
1 | 9/63 | 4 | 5 | 0.351 | 9/64 | 6 | 3 | 0.344 |
2 | 28/63 | 17 | 11 | ** | 28/64 | 22 | 6 | ** |
3 | 13/63 | 9 | 4 | 13/64 | 11 | 2 | ||
Tumor size | ||||||||
> 30 mm | 42/64 | 23 | 19 | 0.475 | 43/65 | 30 | 13 | 0.370 |
< 30 mm | 22/64 | 13 | 9 | 22/65 | 17 | 5 | ||
BMI | ||||||||
> 25 | 25/43 | 15 | 10 | 0.366 | 26/44 | 19 | 7 | 0.186 |
< 25 | 18/43 | 9 | 9 | *** | 18/44 | 16 | 2 | *** |
Sex | ||||||||
Male | 35/64 | 19 | 16 | 0.463 | 35/65 | 29 | 6 | 0.038 |
Female | 29/64 | 17 | 12 | 30/65 | 18 | 12 | ||