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Table 2 Intensity of HIF-1alpha and CAIX compared to clinicopathological variables in pancreatic ductal adenocarcinoma. Statistically significant p values are italicized

From: Weak HIF-1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma

Variable n/N Nuclear HIF-1alpha intensity, n n/N Membranous CAIX intensity, n
   Weak Strong p   Weak Strong p
pT
 T1 4/64 1 3 0.439 4/65 4 0 0.533
 T2 22/64 11 11   22/65 15 7  
 T3 32/64 20 12   33/65 23 10  
 T4 6/64 4 2   6/65 5 1  
Lymph nodes
 Positive 31/64 16 15 0.556 32/65 23 9 0.823
 Negative 32/64 19 13 * 32/65 23 9 *
Stage
 I 18/63 7 11 0.236 18/64 13 5 0.794
 II 39/63 24 15 * 40/64 28 12 *
 III–IV 6/63 4 2   6/64 5 1  
Tumor grade
 1 9/63 4 5 0.351 9/64 6 3 0.344
 2 28/63 17 11 ** 28/64 22 6 **
 3 13/63 9 4   13/64 11 2  
Tumor size
 > 30 mm 42/64 23 19 0.475 43/65 30 13 0.370
 < 30 mm 22/64 13 9   22/65 17 5  
BMI
 > 25 25/43 15 10 0.366 26/44 19 7 0.186
 < 25 18/43 9 9 *** 18/44 16 2 ***
Sex
 Male 35/64 19 16 0.463 35/65 29 6 0.038
 Female 29/64 17 12   30/65 18 12  
  1. *Lymph node status was unavailable for one patient
  2. **Tumor grade was missing from 16 patients
  3. ***BMI was available only for 47 patients