Fig. 1
From: Genomic characterization of colitis-associated colorectal cancer
Differences in molecular pathogenesis of sporadic CRC and CAC. The loss of APC occurs early in the development of sporadic CRC, whereas it is usually a late event in CAC. TP53 mutations appear early in CAC, even prior to the development of dysplasia, but late in sporadic CRC. CRC colorectal cancer, CAC colitis-associated cancer, APC adenomatous polyposis coli, MSI microsatellite instability, COX2 cyclooxygenase 2, KRAS Kirsten rat sarcoma viral oncogene homolog, DCC deleted in colorectal carcinoma, SMAD4 SMAD family member 4, CIN chromosomal instability, TGF-β transforming growth factor-β