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Table 2 Association of EGFR expression categories (percentage) with clinico-pathologic parameters of head and neck squamous cell carcinoma

From: Immunohistochemical expression of epidermal growth factor receptor (EGFR) in South Asian head and neck squamous cell carcinoma: association with various risk factors and clinico-pathologic and prognostic parameters

  n (%) P value
≤ 10% (n = 64) 11–50% (n = 30) 51–70% (n = 14) > 70% (n = 7) Total (n = 115)
Age group
 ≤ 30 years 1 (1.6) 1 (3.3) 2 (14.3) 0 (0) 4 (3.5) 0.334
 31–50 years 34 (53.1) 12 (40) 7 (50) 4 (57.1) 57 (49.6)
 > 50 years 29 (45.3) 17 (56.7) 5 (35.7) 3 (42.9) 54 (47)
Gender
 Male 45 (70.3) 24 (80) 11 (78.6) 5 (71.4) 85 (73.9) 0.793
 Female 19 (29.7) 6 (20) 3 (21.4) 2 (28.6) 30 (26.1)
History of pan (n = 44)
 Yes 14 (56) 7 (70) 2 (66.7) 4 (66.7) 27 (61.4) 0.917
 No 11 (44) 3 (30) 1 (33.3) 2 (33.3) 17 (38.6)
History of smoking (n = 44)
 Yes 4 (16) 0 (0) 0 (0) 0 (0) 4 (9.1) 0.497
 No 21 (84) 10 (100) 3 (100) 6 (100) 40 (90.9)
History of alcohol(n = 44)
 Yes 0 (0) 1 (10) 0 (0) 0 (0) 1 (2.3) 0.432
 No 25 (100) 9 (90) 3 (100) 6 (100) 43 (97.7)
Location of tumor
 Oral cavity 47 (73.4) 18 (60) 10 (71.4) 4 (57.1) 79 (68.7) 0.369
 Lip 1 (1.6) 1 (3.3) 1 (7.1) 0 (0) 3 (2.6)
 Tongue 12 (18.8) 11 (36.7) 3 (21.4) 3 (42.9) 29 (25.2)
 Soft palate 4 (6.3) 0 (0) 0 (0) 0 (0) 4 (3.5)
Tumor stage
 T1 14 (21.9) 13 (43.3) 2 (14.3) 2 (28.6) 31 (27) 0.013
 T2 38 (59.4) 10 (33.3) 4 (28.6) 2 (28.6) 54 (47)
 T3/T4 12 (18.8) 7 (23.3) 8 (57.1) 3 (42.9) 30 (26.1)
Depth of invasion
 < 2 cm 54 (84.4) 28 (93.3) 10 (71.4) 6 (85.7) 98 (85.2) 0.271
 ≥ 2 cm 10 (15.6) 2 (6.7) 4 (28.6) 1 (14.3) 17 (14.8)
Nodal stage
 No 35 (54.7) 20 (66.7) 4 (28.6) 4 (57.1) 63 (54.8) 0.082
 N1 11 (17.2) 2 (6.7) 4 (28.6) 0 (0) 17 (14.8)
 N2a 0 (0) 0 (0) 0 (0) 0 (0) 0 (0)
 N2b 17 (26.6) 6 (20) 6 (42.9) 2 (28.6) 31 (27)
 N2c 0 (0) 2 (6.7) 0 (0) 1 (14.3) 3 (2.6)
 N3 1 (1.6) 0 (0) 0 (0) 0 (0) 1 (0.9)
Extranodal extention
 Not present 51 (79.7) 23 (76.7) 7 (50) 4 (57.1) 85 (73.9) 0.089
 Present 13 (20.3) 7 (23.3) 7 (50) 3 (42.9) 30 (26.1)
Histological subtypes
 Non-keratinizing 10 (15.6) 3 (10) 3 (21.4) 1 (14.3) 17 (14.8) 0.527
 Keratinizing 37 (57.8) 20 (66.7) 5 (35.7) 3 (42.9) 65 (56.5)
 Non-keratinizing with maturation 17 (26.6) 7 (23.3) 6 (42.9) 3 (42.9) 3 (28.7)
Histologic grade
 Grade-I 20 (31.3) 9 (30) 1 (7.1) 1 (14.3) 31 (27) 0.592
 Grade-II 37 (57.8) 18 (60) 11 (78.6) 5 (71.4) 71 (61.7)
 Grade-III 7 (10.9) 3 (10) 2 (14.3) 1 (14.3) 13 (11.3)
Lymphovascular invasion
 Not present 63 (98.4) 30 (100) 14 (100) 7 (100) 114 (99.1) 1.000
 Present 1 (1.6) 0 (0) 0 (0) 0 (0) 1 (0.9)
Perineural invasion
 Not present 57 (89.1) 26 (86.7) 12 (85.7) 4 (57.1) 99 (86.1) 0.159
 Present 7 (10.9) 4 (13.3) 2 (14.3) 3 (42.9) 16 (13.9)
Radiation (n = 45)
 Yes 17 (65.4) 5 (50) 0 (0) 3 (50) 25 (55.6) 0.174
 No 9 (34.6) 5 (50) 3 (100) 3 (50) 20 (44.4)
Chemotherapy(n = 45)
 Yes 17 (65.4) 4 (40) 0 (0) 3 (50) 24 (53.3) 0.128
 No 9 (34.6) 6 (60) 3 (100) 3 (50) 21 (46.7)
  1. Chi-square test was applied
  2. P value ≤ 0.05 was considered as significant