Table 2 Association of EGFR expression categories (percentage) with clinico-pathologic parameters of head and neck squamous cell carcinoma
n (%) | P value | |||||
|---|---|---|---|---|---|---|
≤ 10% (n = 64) | 11–50% (n = 30) | 51–70% (n = 14) | > 70% (n = 7) | Total (n = 115) | ||
Age group | ||||||
≤ 30 years | 1 (1.6) | 1 (3.3) | 2 (14.3) | 0 (0) | 4 (3.5) | 0.334 |
31–50 years | 34 (53.1) | 12 (40) | 7 (50) | 4 (57.1) | 57 (49.6) | |
> 50 years | 29 (45.3) | 17 (56.7) | 5 (35.7) | 3 (42.9) | 54 (47) | |
Gender | ||||||
Male | 45 (70.3) | 24 (80) | 11 (78.6) | 5 (71.4) | 85 (73.9) | 0.793 |
Female | 19 (29.7) | 6 (20) | 3 (21.4) | 2 (28.6) | 30 (26.1) | |
History of pan (n = 44) | ||||||
Yes | 14 (56) | 7 (70) | 2 (66.7) | 4 (66.7) | 27 (61.4) | 0.917 |
No | 11 (44) | 3 (30) | 1 (33.3) | 2 (33.3) | 17 (38.6) | |
History of smoking (n = 44) | ||||||
Yes | 4 (16) | 0 (0) | 0 (0) | 0 (0) | 4 (9.1) | 0.497 |
No | 21 (84) | 10 (100) | 3 (100) | 6 (100) | 40 (90.9) | |
History of alcohol(n = 44) | ||||||
Yes | 0 (0) | 1 (10) | 0 (0) | 0 (0) | 1 (2.3) | 0.432 |
No | 25 (100) | 9 (90) | 3 (100) | 6 (100) | 43 (97.7) | |
Location of tumor | ||||||
Oral cavity | 47 (73.4) | 18 (60) | 10 (71.4) | 4 (57.1) | 79 (68.7) | 0.369 |
Lip | 1 (1.6) | 1 (3.3) | 1 (7.1) | 0 (0) | 3 (2.6) | |
Tongue | 12 (18.8) | 11 (36.7) | 3 (21.4) | 3 (42.9) | 29 (25.2) | |
Soft palate | 4 (6.3) | 0 (0) | 0 (0) | 0 (0) | 4 (3.5) | |
Tumor stage | ||||||
T1 | 14 (21.9) | 13 (43.3) | 2 (14.3) | 2 (28.6) | 31 (27) | 0.013 |
T2 | 38 (59.4) | 10 (33.3) | 4 (28.6) | 2 (28.6) | 54 (47) | |
T3/T4 | 12 (18.8) | 7 (23.3) | 8 (57.1) | 3 (42.9) | 30 (26.1) | |
Depth of invasion | ||||||
< 2 cm | 54 (84.4) | 28 (93.3) | 10 (71.4) | 6 (85.7) | 98 (85.2) | 0.271 |
≥ 2 cm | 10 (15.6) | 2 (6.7) | 4 (28.6) | 1 (14.3) | 17 (14.8) | |
Nodal stage | ||||||
No | 35 (54.7) | 20 (66.7) | 4 (28.6) | 4 (57.1) | 63 (54.8) | 0.082 |
N1 | 11 (17.2) | 2 (6.7) | 4 (28.6) | 0 (0) | 17 (14.8) | |
N2a | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | |
N2b | 17 (26.6) | 6 (20) | 6 (42.9) | 2 (28.6) | 31 (27) | |
N2c | 0 (0) | 2 (6.7) | 0 (0) | 1 (14.3) | 3 (2.6) | |
N3 | 1 (1.6) | 0 (0) | 0 (0) | 0 (0) | 1 (0.9) | |
Extranodal extention | ||||||
Not present | 51 (79.7) | 23 (76.7) | 7 (50) | 4 (57.1) | 85 (73.9) | 0.089 |
Present | 13 (20.3) | 7 (23.3) | 7 (50) | 3 (42.9) | 30 (26.1) | |
Histological subtypes | ||||||
Non-keratinizing | 10 (15.6) | 3 (10) | 3 (21.4) | 1 (14.3) | 17 (14.8) | 0.527 |
Keratinizing | 37 (57.8) | 20 (66.7) | 5 (35.7) | 3 (42.9) | 65 (56.5) | |
Non-keratinizing with maturation | 17 (26.6) | 7 (23.3) | 6 (42.9) | 3 (42.9) | 3 (28.7) | |
Histologic grade | ||||||
Grade-I | 20 (31.3) | 9 (30) | 1 (7.1) | 1 (14.3) | 31 (27) | 0.592 |
Grade-II | 37 (57.8) | 18 (60) | 11 (78.6) | 5 (71.4) | 71 (61.7) | |
Grade-III | 7 (10.9) | 3 (10) | 2 (14.3) | 1 (14.3) | 13 (11.3) | |
Lymphovascular invasion | ||||||
Not present | 63 (98.4) | 30 (100) | 14 (100) | 7 (100) | 114 (99.1) | 1.000 |
Present | 1 (1.6) | 0 (0) | 0 (0) | 0 (0) | 1 (0.9) | |
Perineural invasion | ||||||
Not present | 57 (89.1) | 26 (86.7) | 12 (85.7) | 4 (57.1) | 99 (86.1) | 0.159 |
Present | 7 (10.9) | 4 (13.3) | 2 (14.3) | 3 (42.9) | 16 (13.9) | |
Radiation (n = 45) | ||||||
Yes | 17 (65.4) | 5 (50) | 0 (0) | 3 (50) | 25 (55.6) | 0.174 |
No | 9 (34.6) | 5 (50) | 3 (100) | 3 (50) | 20 (44.4) | |
Chemotherapy(n = 45) | ||||||
Yes | 17 (65.4) | 4 (40) | 0 (0) | 3 (50) | 24 (53.3) | 0.128 |
No | 9 (34.6) | 6 (60) | 3 (100) | 3 (50) | 21 (46.7) | |