Table 2 Adverse events associated with chemotherapy
|  | DCF, N = 37 | bDCF, N = 22 | p value |
|---|---|---|---|
Number of coursesa | 2.3 ± 1.3 | 2.7 ± 1.2 | 0.303 |
Discontinuance of next course due to AE | 6 (16.2) | 2 (9.1) | 0.440 |
Dose reduction | 8 (21.6) | 3 (13.6) | 0.446 |
Hematologic toxicity (grades 3–4) | |||
 Neutropenia | 30 (81.1) | 9 (40.9) | 0.002 |
 Febrile neutropenia | 5 (13.5) | 2 (9.1) | 0.612 |
 Anemia | 1 (2.7) | 0 | 0.437 |
 Thrombocytopenia | 1 (2.7) | 0 | 0.437 |
Non-hematologic toxicity (grades 3–4) | |||
 Nausea/vomiting | 1 (2.7) | 1 (4.5) | 0.705 |
 Diarrhea | 10 (27) | 5 (22.7) | 0.714 |
 Mucositis oral | 6 (16.2) | 1 (4.5) | 0.180 |
 Anorexia | 7 (18.9) | 0 | 0.030 |
Days to operationab (range) | 52.3 ± 14.7 (30–86) | 45.1 ± 13.5 (30–83) | 0.067 |
Preoperative white blood cell count (/μL)a | 5929.2 ± 2094 | 5017.3 ± 1777.7 | 0.091 |
Preoperative neutrophil count (/μL)a | 3529.9 ± 1819.5 | 2950.2 ± 1313.1 | 0.199 |