Fig. 1From: Therapeutic and prophylactic gastrectomy in a family with hereditary diffuse gastric cancer secondary to a CDH1 mutation: a case seriesPatient 1 tissue biopsy. a Low-power field of hematoxylin and eosin (H&E) staining of gastric mucosa showing disorganized infiltrative sheets of cells invading the lamina propria. b Varying degrees of high-power fields demonstrating sheets of signet ring cells (arrows) infiltrating the muscularis mucosa. c Immunohistochemistry (IHC) with cytokeratin 7 confirming tumor tissue infiltrating muscularis mucosaBack to article page