Table 4 Hub genes and its predicted miRNAs

COL1A1

hsa-let-7d hsa-miR-98 hsa-let-7a hsa-let-7 g hsa-let-7i

149

COL1A2

hsa-miR-29c hsa-let-7c hsa-miR-25 hsa-miR-29a hsa-miR-29b

91

COL3A1

hsa-miR-29b hsa-let-7 g hsa-let-7f hsa-let-7i hsa-let-7a

85

COL4A1

hsa-miR-29a hsa-miR-29b hsa-miR-29c hsa-miR-148a hsa-let-7c

118

COL6A3

hsa-miR-29c hsa-miR-29a hsa-miR-29b hsa-miR-206 hsa-miR-330-3p

108

MMP7

hsa-miR-297 hsa-miR-641 hsa-miR-19b hsa-miR-122 hsa-miR-380

32

SERPINH1

hsa-miR-200b hsa-miR-24 hsa-miR-346 hsa-miR-561 hsa-miR-637

56

SPARC

hsa-miR-29a hsa-miR-299-3p hsa-miR-29c hsa-miR-203 hsa-miR-29b

206

SPP1

hsa-miR-220b hsa-miR-127-5p hsa-miR-181c hsa-miR-181a hsa-miR-181b

72

THBS2

hsa-miR-607 hsa-miR-891b hsa-miR-616 hsa-miR-519a hsa-miR-221

184

TIMP1

hsa-miR-484 hsa-miR-892a hsa-miR-1293 hsa-miR-1292

4

VCAN

hsa-miR-203 hsa-miR-144 hsa-miR-632 hsa-miR-135b hsa-miR-136

57