Fig. 3

c-Myc bound to FoxM1 gene promoter. a The schematic graph of relative positions of c-Myc binding sites in FoxM1 gene promoter. b PC-3 cells were transfected with c-Myc overexpression plasmid and small interference RNA. The binding of c-Myc on site 1 of FoxM1 promoter in c-Myc overexpression group and control group was detected by ChIP assay. c The binding of c-Myc on site 2 of FoxM1 promoter in c-Myc overexpression group and control group was detected by ChIP assay. d The binding of c-Myc on site 1 of FoxM1 promoter in c-Myc interference group and control group was detected by ChIP assay. e The binding of c-Myc on site 2 of FoxM1 promoter in c-Myc interference group and control group was detected by ChIP assay. (*p < 0.05, **p < 0.01)