Fig. 5
From: The rs1024611 in the CCL2 gene and risk of gynecological cancer in Asians: a meta-analysis
Schematic plot of CCL2 involved in tumor progression. The monocytes expressing CCL2 in blood vessel were recruited to tumor site through CCR2, TAMs when stimulated by cell factors (M-CSF-1, VEGF-A, IL-4, IL-10, IL-13), then TAMs induce endothelial cell migration by secreting TGF-β, EGF, FGF, VEGF, and PDGF, and these TAM-derived factors could promote tumor angiogenesis and CCL2-involved tumor progression. CCL2 chemokine (C-C motif) ligand 2, CCR2 CC chemokine receptor, TAMs tumor-associated macrophages, M-CSF macrophage colony-stimulating factor, VEGF vascular permeability factor, IL interleukin