Table 3 Univariate and multivariate analyses of overall survival for initial HR-positive patients with adjuvant endocrinotherapy after surgery
Characteristics | N (%) | OS | |||
|---|---|---|---|---|---|
Uv | Mv | ||||
P | HR (95% CI) | P | HR (95% CI) | ||
Age, years | 0.089 | ||||
≤ 50 | 146 (68.5) | 1.00 | |||
> 50 | 67 (31.5) | 2.007 (0.899–4.482) | |||
Initial tumor stage | 0.073 | ||||
T1 | 38 (17.8) | 1.00 | |||
T2 | 107 (50.2) | 0.757 | 1.230 (0.333–4.457) | ||
T3 or T4 | 68 (31.9) | 0.094 | 2.967 (0.832–10.579) | ||
Initial node status | 0.242 | ||||
Negative | 26 (12.2) | 1.00 | |||
Positive | 187 (87.8) | 3.302 (0.446–24.467) | |||
Nuclear grade | 0.335 | ||||
1 or 2 | 73 (34.3) | 1.00 | |||
3 | 55 (25.8) | 1.651 (0.596–4.577) | |||
NA | 85 (39.9) | ||||
Histology | 0.042 | 0.214 | |||
IDC | 183 (85.9) | 1.00 | 1.00 | ||
Mixed | 17 (8.0) | 0.19 | 3.334 (1.221–9.104) | 0.154 | 2.196 (0.745–6.469) |
Other | 13 (6.1) | 0.177 | 2.339 (0.681–8.039) | 0.208 | 2.228 (0.641–7.740) |
Initial HER2 status | 0.417 | ||||
Negative | 182 (85.4) | 1.00 | |||
Positive | 31 (14.5) | 0.549 (0.129–2.337) | |||
Initial Ki-67 status | 0.128 | ||||
< 15% | 57 (26.8) | 1.00 | |||
≥ 15% | 156 (73.2) | 0.532 (0.236–1.199) | |||
NAC regimens | 0.002 | 0.015 | |||
Anthracycline-based | 65 (30.5) | 1.00 | 1.00 | ||
Anthracycline- and Taxane-based | 133 (62.4) | 0.574 | 1.378 (0.451–4.208) | 0.642 | 1.307 (0.424–4.031) |
Taxane-based | 15 (7.0) | 0.003 | 6.712 (1.893–23.794) | 0.013 | 5.242 (1.408–19.509) |
Any receptor conversion | 0.588 | ||||
No | 167 (78.4) | 1.00 | |||
Yes | 46 (21.6) | 1.291 (0.512–3.259) | |||
Tumor size at surgery | 0.223 | ||||
≤ 2 cm | 88 (41.3) | 1.00 | |||
> 2 and ≤ 5 cm | 114 (53.5) | 0.313 | 1.596 (0.644–3.957) | ||
> 5 cm | 11 (5.2) | 0.087 | 3.263 (0.843–12.633) | ||
Node status at surgery | 0.071 | ||||
Negative | 49 (23.0) | 1.00 | |||
Positive | 164 (77.0) | 3.802 (0.893–16.182) | |||
HER2 status at surgery | 0.976 | ||||
Negative | 184 (86.4) | 1.00 | |||
Positive | 29 (13.6) | 0.982 (0.292–3.294) | |||
Ki-67 status at surgery | 0.676 | ||||
< 15% | 116 (54.5) | 1.00 | |||
≥ 15% | 97 (45.5) | 1.187 (0.531–2.654) | |||
Radiotherapy | 0.859 | ||||
No | 57 (26.8) | 1.00 | |||
Yes | 156 (73.2) | 1.088 (0.432–2.740) | |||