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Table 3 The NSCLC highly saturated pathways by targets of upregulated (red) and downregulated (blue) microRNAs

From: Analysis of microRNA (miRNA) expression profiles reveals 11 key biomarkers associated with non-small cell lung cancer

Term

Count

p value

Fold enrichment

Benjamini

FDR

GO:0000122~negative regulation of transcription from RNA polymerase II promoter

56

4.86E−10

2.518139934

1.30E−06

8.63E−07

GO:0045944~positive regulation of transcription from RNA polymerase II promoter

62

9.15E−08

2.06555926

1.22E−04

1.63E−04

GO:0060021~palate development

13

3.25E−06

5.557193787

0.002893

0.005773

GO:0006366~transcription from RNA polymerase II promoter

36

8.39E−06

2.292001365

0.005597

0.014915

GO:0008284~positive regulation of cell proliferation

33

2.87E−05

2.258248746

0.015224

0.050944

GO:0001974~blood vessel remodeling

8

7.27E−05

7.523585434

0.03191

0.129182

GO:0036092~phosphatidylinositol-3-phosphate biosynthetic process

9

1.02E−04

6.045738295

0.038266

0.181279

GO:0006351~transcription, DNA-templated

88

1.35E−04

1.483903889

0.044245

0.24022

GO:0006357~regulation of transcription from RNA polymerase II promoter

29

1.69E−04

2.18433616

0.049011

0.300012

GO:0045944~positive regulation of transcription from RNA polymerase II promoter

151

8.98E−10

1.635197256

4.34E−06

1.70E−06

GO:0045893~positive regulation of transcription, DNA-templated

80

7.28E−06

1.658786271

0.017456

0.013808

GO:0006366~transcription from RNA polymerase II promoter

78

2.54E−05

1.614188342

0.024278

0.048167

GO:0048013~ephrin receptor signaling pathway

22

3.15E−05

2.736997347

0.025043

0.059642

GO:0007264~small GTPase mediated signal transduction

45

2.37E−05

1.941381916

0.028286

0.044989

GO:0090190~positive regulation of branching involved in ureteric bud morphogenesis

10

2.05E−05

5.631142867

0.032546

0.038909

GO:0032331~negative regulation of chondrocyte differentiation

9

6.40E−05

5.664267237

0.043258

0.121289

GO:0007010~cytoskeleton organization

32

7.75E−05

2.126543393

0.045758

0.146799