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Table 2 Cell proliferation assay of nanomicelles or free drugs at 48 ha

From: Gefitinib-loaded DSPE-PEG2000 nanomicelles with CD133 aptamers target lung cancer stem cells

IC50 (μg/mL)

A549

A431

CD133+

CD133−

CD133+

CD133−

Gefitinib

78.6 ± 22.5

31.3 ± 13.5

35.8 ± 17.3

17.9 ± 8.4

M-Gef

31.9 ± 11.1

21.5 ± 13.6

17.6 ± 9.9

11.6 ± 9.5

M-Gef-CD133

8.5 ± 5.7

19.8 ± 8.4

4.7 ± 3.2

13.3 ± 5.6

M-CD133

> 3000

> 3000

> 3000

> 3000

  1. aData are expressed as mean ± SD (n = 3). The items are defined as follows: M-Gef indicates gefitinib-loaded nanomicelles, M-Gef-CD133 indicates gefitinib-loaded nanomicelles conjugated with CD133 aptamers, and M-CD133 indicates blank nanomicelles conjugated with CD133 aptamers
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World Journal of Surgical Oncology

ISSN: 1477-7819

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