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Table 2 Cell proliferation assay of nanomicelles or free drugs at 48 ha

From: Gefitinib-loaded DSPE-PEG2000 nanomicelles with CD133 aptamers target lung cancer stem cells

IC50 (μg/mL) A549 A431
CD133+ CD133 CD133+ CD133
Gefitinib 78.6 ± 22.5 31.3 ± 13.5 35.8 ± 17.3 17.9 ± 8.4
M-Gef 31.9 ± 11.1 21.5 ± 13.6 17.6 ± 9.9 11.6 ± 9.5
M-Gef-CD133 8.5 ± 5.7 19.8 ± 8.4 4.7 ± 3.2 13.3 ± 5.6
M-CD133 > 3000 > 3000 > 3000 > 3000
  1. aData are expressed as mean ± SD (n = 3). The items are defined as follows: M-Gef indicates gefitinib-loaded nanomicelles, M-Gef-CD133 indicates gefitinib-loaded nanomicelles conjugated with CD133 aptamers, and M-CD133 indicates blank nanomicelles conjugated with CD133 aptamers