Table 3 Distribution of long non-coding RNA genes in case and control subjects and their associations with risk of pancreatic cancer
Gene | SNPs | Patients | Controls | ORa (95%CI) | P |
|---|---|---|---|---|---|
N (%) | N (%) | ||||
Discovery set | N = 416 | N = 416 | |||
HOTTIP | rs1859168 | ||||
AA | 80 (19.2) | 60 (14.4) | 1 | ||
AC | 220 (52.9) | 175 (42.1) | 0.99 (0.66–1.49) | 0.973 | |
CC | 116 (27.9) | 181 (43.5) | 0.71 (0.57–0.88) | 0.002 | |
Dominant model | 0.74 (0.51–1.08) | 0.122 | |||
Recessive model | 0.51 (0.38–0.68) | < 0.001 | |||
Additive model | 0.67 (0.51–0.82) | < 0.001 | |||
HOTAIR | rs4759314 | ||||
AA | 333 (80.0) | 325 (78.1) | 1 | ||
AG | 75 (18.0) | 82 (19.7) | 0.91 (0.64–1.31) | 0.621 | |
GG | 8 (2.0) | 9 (2.2) | 0.99 (0.60–1.64) | 0.957 | |
Dominant model | 0.92 (0.65–1.30) | 0.621 | |||
Recessive model | 0.96 (0.35–2.61) | 0.928 | |||
Additive model | 0.93 (0.69–1.26) | 0.646 | |||
H19 | rs217727 | ||||
CC | 133 (32.0) | 128 (30.8) | 1 | ||
CT | 200 (48.0) | 196 (47.1) | 1.04 (0.75–1.44) | 0.821 | |
TT | 83 (20.0) | 92 (22.1) | 0.93 (0.76–1.13) | 0.462 | |
Dominant model | 0.98 (0.72–1.32) | 0.877 | |||
Recessive model | 0.84 (0.59–1.19) | 0.325 | |||
Additive model | 0.94 (0.78–1.14) | 0.509 | |||
Validation set | N = 505 | N = 505 | |||
HOTTIP | rs1859168 | ||||
AA | 105 (20.8) | 76 (15.0) | 1 | ||
AC | 277 (54.9) | 246 (48.7) | 0.86 (0.60–1.22) | 0.387 | |
CC | 123 (24.4) | 183 (36.2) | 0.70 (0.58–0.85) | < 0.001 | |
Dominant model | 0.71 (0.51–0.99) | 0.042 | |||
Recessive model | 0.56 (0.43–0.75) | < 0.001 | |||
Additive model | 0.69 (0.57–0.84) | < 0.001 | |||
Pooled analysis | N = 921 | N = 921 | |||
HOTTIP | rs1859168 | ||||
AA | 185 (20.1) | 136 (14.8) | 1 | ||
AC | 497 (54.0) | 421 (45.7) | 0.92 (0.70–1.20) | 0.522 | |
CC | 239 (26.0) | 364 (39.5) | 0.71 (0.61–0.81) | < 0.001 | |
Dominant model | 0.72 (0.56–0.93) | 0.010 | |||
Recessive model | 0.54 (0.44–0.66) | < 0.001 | |||
Additive model | 0.68 (0.59–0.78) | < 0.001 | |||