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Table 3 Distribution of long non-coding RNA genes in case and control subjects and their associations with risk of pancreatic cancer

From: rs1859168 A > C polymorphism regulates HOTTIP expression and reduces risk of pancreatic cancer in a Chinese population

Gene SNPs Patients Controls ORa (95%CI) P
N (%) N (%)
Discovery set   N = 416 N = 416   
 HOTTIP rs1859168     
AA 80 (19.2) 60 (14.4) 1  
AC 220 (52.9) 175 (42.1) 0.99 (0.66–1.49) 0.973
CC 116 (27.9) 181 (43.5) 0.71 (0.57–0.88) 0.002
Dominant model 0.74 (0.51–1.08) 0.122
Recessive model 0.51 (0.38–0.68) < 0.001
Additive model 0.67 (0.51–0.82) < 0.001
 HOTAIR rs4759314     
AA 333 (80.0) 325 (78.1) 1  
AG 75 (18.0) 82 (19.7) 0.91 (0.64–1.31) 0.621
GG 8 (2.0) 9 (2.2) 0.99 (0.60–1.64) 0.957
Dominant model 0.92 (0.65–1.30) 0.621
Recessive model 0.96 (0.35–2.61) 0.928
Additive model 0.93 (0.69–1.26) 0.646
 H19 rs217727     
CC 133 (32.0) 128 (30.8) 1  
CT 200 (48.0) 196 (47.1) 1.04 (0.75–1.44) 0.821
TT 83 (20.0) 92 (22.1) 0.93 (0.76–1.13) 0.462
Dominant model 0.98 (0.72–1.32) 0.877
Recessive model 0.84 (0.59–1.19) 0.325
Additive model 0.94 (0.78–1.14) 0.509
Validation set   N = 505 N = 505   
 HOTTIP rs1859168     
AA 105 (20.8) 76 (15.0) 1  
AC 277 (54.9) 246 (48.7) 0.86 (0.60–1.22) 0.387
CC 123 (24.4) 183 (36.2) 0.70 (0.58–0.85) < 0.001
Dominant model 0.71 (0.51–0.99) 0.042
Recessive model 0.56 (0.43–0.75) < 0.001
Additive model 0.69 (0.57–0.84) < 0.001
Pooled analysis   N = 921 N = 921   
 HOTTIP rs1859168     
AA 185 (20.1) 136 (14.8) 1  
AC 497 (54.0) 421 (45.7) 0.92 (0.70–1.20) 0.522
CC 239 (26.0) 364 (39.5) 0.71 (0.61–0.81) < 0.001
Dominant model 0.72 (0.56–0.93) 0.010
Recessive model 0.54 (0.44–0.66) < 0.001
Additive model 0.68 (0.59–0.78) < 0.001
  1. ORs and P values were obtained from logistic regression models with adjustment for age, gender, body mass index, smoking status, alcohol intake, hypertension, history of pancreatitis, diabetes mellitus, and family history of cancer