|
Gene
|
SNPs
|
Patients
|
Controls
|
ORa (95%CI)
|
P
|
|---|
|
N (%)
|
N (%)
|
|---|
|
Discovery set
| |
N = 416
|
N = 416
| | |
|
HOTTIP
|
rs1859168
| | | | |
|
AA
|
80 (19.2)
|
60 (14.4)
|
1
| |
|
AC
|
220 (52.9)
|
175 (42.1)
|
0.99 (0.66–1.49)
|
0.973
|
|
CC
|
116 (27.9)
|
181 (43.5)
|
0.71 (0.57–0.88)
|
0.002
|
|
Dominant model
|
0.74 (0.51–1.08)
|
0.122
|
|
Recessive model
|
0.51 (0.38–0.68)
|
< 0.001
|
|
Additive model
|
0.67 (0.51–0.82)
|
< 0.001
|
|
HOTAIR
|
rs4759314
| | | | |
|
AA
|
333 (80.0)
|
325 (78.1)
|
1
| |
|
AG
|
75 (18.0)
|
82 (19.7)
|
0.91 (0.64–1.31)
|
0.621
|
|
GG
|
8 (2.0)
|
9 (2.2)
|
0.99 (0.60–1.64)
|
0.957
|
|
Dominant model
|
0.92 (0.65–1.30)
|
0.621
|
|
Recessive model
|
0.96 (0.35–2.61)
|
0.928
|
|
Additive model
|
0.93 (0.69–1.26)
|
0.646
|
|
H19
|
rs217727
| | | | |
|
CC
|
133 (32.0)
|
128 (30.8)
|
1
| |
|
CT
|
200 (48.0)
|
196 (47.1)
|
1.04 (0.75–1.44)
|
0.821
|
|
TT
|
83 (20.0)
|
92 (22.1)
|
0.93 (0.76–1.13)
|
0.462
|
|
Dominant model
|
0.98 (0.72–1.32)
|
0.877
|
|
Recessive model
|
0.84 (0.59–1.19)
|
0.325
|
|
Additive model
|
0.94 (0.78–1.14)
|
0.509
|
|
Validation set
| |
N = 505
|
N = 505
| | |
|
HOTTIP
|
rs1859168
| | | | |
|
AA
|
105 (20.8)
|
76 (15.0)
|
1
| |
|
AC
|
277 (54.9)
|
246 (48.7)
|
0.86 (0.60–1.22)
|
0.387
|
|
CC
|
123 (24.4)
|
183 (36.2)
|
0.70 (0.58–0.85)
|
< 0.001
|
|
Dominant model
|
0.71 (0.51–0.99)
|
0.042
|
|
Recessive model
|
0.56 (0.43–0.75)
|
< 0.001
|
|
Additive model
|
0.69 (0.57–0.84)
|
< 0.001
|
|
Pooled analysis
| |
N = 921
|
N = 921
| | |
|
HOTTIP
|
rs1859168
| | | | |
|
AA
|
185 (20.1)
|
136 (14.8)
|
1
| |
|
AC
|
497 (54.0)
|
421 (45.7)
|
0.92 (0.70–1.20)
|
0.522
|
|
CC
|
239 (26.0)
|
364 (39.5)
|
0.71 (0.61–0.81)
|
< 0.001
|
|
Dominant model
|
0.72 (0.56–0.93)
|
0.010
|
|
Recessive model
|
0.54 (0.44–0.66)
|
< 0.001
|
|
Additive model
|
0.68 (0.59–0.78)
|
< 0.001
|
- ORs and P values were obtained from logistic regression models with adjustment for age, gender, body mass index, smoking status, alcohol intake, hypertension, history of pancreatitis, diabetes mellitus, and family history of cancer
