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Table 2 Prognostic implications of linitis plastica in the literature

From: The significance of a nineteenth century definition in the era of genomics: linitis plastica

Author, year

Study design

LP sample size

Stage (%)

pT1/2/3/4 (%)

pN0/1/2/3 (%)

M1 (%)

CY1 (%)

P1 (%)

Surgical resection (%)

Total gastrectomy (%)

R1/R2 (%)

Median survival (months)

Median survival unresected (months)

Median survival resected (months)

Median survival R0 (months)

1Y-OS (%)

3Y-OSS (%)

5Y-OS (%)

Impact of LP on prognosis after adjustment

Aranha, 1989 [76]

Retrospective cohort

26

–

–

–

–

–

–

50

85

–

6.9

6.6

7.2

–

–

–

–

Not performed

Hamy, 1999 [77]

Retrospective cohort

86

–

5.5(T1 + T2)/4/90.5

–

–

–

–

86

69

–

–

–

12

–

50d

40d

10d

Not performed

Kodera, 2004 [70]

Retrospective cohort

47

–

0/2/72/26

2/13/23/45

–

43

43

83

–

47

14

     

10

Not performed

Kodera, 2008 [75]

Retrospective cohort

178

–

-/-/-/89

15/23/21/41

–

–

44

84

77

45

13.8

7.8

–

30.2

–

–

–

Not performed

Schauer, 2011 [15]

Retrospective cohort

120

–

0/0/65/35

13/19/18/50

H1: 10%;

LYMPH1: 20%

16

33

100

62.5

69

8

–

8

17

–

–

8d

Not performed

Endo, 2012 [16]

Retrospective cohort

19

5/5/58/32

0/11/68/21

N+: 89.5%

–

53

46

100

–

–

9a

–

9a

–

26d

21d

7d

Not performed

Pedrazzani, 2012 [14]

Retrospective cohort

102

–

0/78(T2 + T3)/22

4/37/42/17

–

–

–

59

–

31

5.7

2.8

–

16

68e

14e

4e

Not performed

Jafferbhoy, 2013 [19]

Case series

8

–

–

–

25

–

 

0

–

–

–

–

–

–

–

–

–

Not performed

Blackham, 2016 [17]

Retrospective cohort

58

III-IV: 90%

2/2/43/53

15/14/28/43

–

–

–

100

88

34

11.6

–

11.6

21.5a

–

24d

15d

Nob

Thompson, 2016 [78]

Retrospective cohort

54

–

6/12/53/29

24/24/6/41

52

–

–

31

–

35

–

3.6

16.7

–

–

–

–

Noc

  1. 1Y-OS 1-year overall survival, 3Y-OS 3-year overall survival, 5Y-OS 5-year overall survival
  2. aExtracted from the Kaplan-Meier curve
  3. bAdjustment by stage and optimal resection status in comparison with non-LP patients
  4. cAdjustment by optimal resection status in comparison with non-LP patients
  5. dAfter resection
  6. eAfter R0 resection