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Table 3 Univariate and multivariate analyses of clinical characteristics according to lymph node metastasis

From: Predictive value of preoperative peripheral blood neutrophil/lymphocyte ratio for lymph node metastasis in patients of resectable pancreatic neuroendocrine tumors: a nomogram-based study

Characteristics Univariate Multivariate
HR (CI 95%) p HR (CI 95%) p
Gender
 Male 2.5 (0.809, 7.722) 0.111   
 Female     
Age
 Age ≤60 0.833 (0.260, 2.672) 0.759   
 Age >60     
TNM staging of ENETS in 2006
 T1, T2 19.500 (4.047, 93.951) <0.001 11.940 (2.098, 67.965) 0.005
 T3, T4     
New grading classifications of WHO in 2010
 NET G1 + G2 16.625 (3.986, 69.349) <0.001 10.378 (1.399, 77) 0.022
 NEC G3     
Tumor thrombus
 Yes 14.182 (2.319, 86.74) 0.004 0.603 (0.049, 7.429) 0.693
 No     
AFP
 Normal 1.008 (0.993, 1.023) 0.317   
 Abnormal     
CA199
 Normal 0.989 (0.938, 1.043) 0.684   
 Abnormal     
CEA
 Normal 1.014 (0.687, 1.497) 0.943   
 Abnormal     
CA125
 Normal 1.033 (0.969, 1.102) 0.320   
 Abnormal     
NLR ≤2.056 7.429 (1.934, 28.540) 0.003 6.740 (1.298, 34.998) 0.023
NLR >2.056     
Functional tumor
 Yes 0.214 (0.026, 1.734) 0.149   
 No     
  1. NET neuroendocrine tumor, NEC neuroendocrine carcinoma, AFP alpha-fetoprotein; CA199 carbohydrate antigen 199, CEA carcinoembryonic antigen, CA125 carbohydrate antigen 125