Predictive value of preoperative peripheral blood neutrophil/lymphocyte ratio for lymph node metastasis in patients of resectable pancreatic neuroendocrine tumors: a nomogram-based study

Table 3 Univariate and multivariate analyses of clinical characteristics according to lymph node metastasis

Characteristics	Univariate		Multivariate
Characteristics	HR (CI 95%)	p	HR (CI 95%)	p
Gender
Male	2.5 (0.809, 7.722)	0.111
Female
Age
Age ≤60	0.833 (0.260, 2.672)	0.759
Age >60
TNM staging of ENETS in 2006
T1, T2	19.500 (4.047, 93.951)	<0.001	11.940 (2.098, 67.965)	0.005
T3, T4
New grading classifications of WHO in 2010
NET G1 + G2	16.625 (3.986, 69.349)	<0.001	10.378 (1.399, 77)	0.022
NEC G3
Tumor thrombus
Yes	14.182 (2.319, 86.74)	0.004	0.603 (0.049, 7.429)	0.693
No
AFP
Normal	1.008 (0.993, 1.023)	0.317
Abnormal
CA199
Normal	0.989 (0.938, 1.043)	0.684
Abnormal
CEA
Normal	1.014 (0.687, 1.497)	0.943
Abnormal
CA125
Normal	1.033 (0.969, 1.102)	0.320
Abnormal
NLR ≤2.056	7.429 (1.934, 28.540)	0.003	6.740 (1.298, 34.998)	0.023
NLR >2.056
Functional tumor
Yes	0.214 (0.026, 1.734)	0.149
No

NET neuroendocrine tumor, NEC neuroendocrine carcinoma, AFP alpha-fetoprotein; CA199 carbohydrate antigen 199, CEA carcinoembryonic antigen, CA125 carbohydrate antigen 125

ISSN: 1477-7819