|
Characteristics
|
Univariate
|
Multivariate
|
|---|
|
HR (CI 95%)
|
p
|
HR (CI 95%)
|
p
|
|---|
|
Gender
|
|
Male
|
2.5 (0.809, 7.722)
|
0.111
| | |
|
Female
| | | | |
|
Age
|
|
Age ≤60
|
0.833 (0.260, 2.672)
|
0.759
| | |
|
Age >60
| | | | |
|
TNM staging of ENETS in 2006
|
|
T1, T2
|
19.500 (4.047, 93.951)
|
<0.001
|
11.940 (2.098, 67.965)
|
0.005
|
|
T3, T4
| | | | |
|
New grading classifications of WHO in 2010
|
|
NET G1 + G2
|
16.625 (3.986, 69.349)
|
<0.001
|
10.378 (1.399, 77)
|
0.022
|
|
NEC G3
| | | | |
|
Tumor thrombus
|
|
Yes
|
14.182 (2.319, 86.74)
|
0.004
|
0.603 (0.049, 7.429)
|
0.693
|
|
No
| | | | |
|
AFP
|
|
Normal
|
1.008 (0.993, 1.023)
|
0.317
| | |
|
Abnormal
| | | | |
|
CA199
|
|
Normal
|
0.989 (0.938, 1.043)
|
0.684
| | |
|
Abnormal
| | | | |
|
CEA
|
|
Normal
|
1.014 (0.687, 1.497)
|
0.943
| | |
|
Abnormal
| | | | |
|
CA125
|
|
Normal
|
1.033 (0.969, 1.102)
|
0.320
| | |
|
Abnormal
| | | | |
|
NLR ≤2.056
|
7.429 (1.934, 28.540)
|
0.003
|
6.740 (1.298, 34.998)
|
0.023
|
|
NLR >2.056
| | | | |
|
Functional tumor
|
|
Yes
|
0.214 (0.026, 1.734)
|
0.149
| | |
|
No
| | | | |
-
NET neuroendocrine tumor, NEC neuroendocrine carcinoma, AFP alpha-fetoprotein; CA199 carbohydrate antigen 199, CEA carcinoembryonic antigen, CA125 carbohydrate antigen 125
