Table 2 Expression of MSi markers in colorectal carcinoma and its correlation with histological parameters
Characteristics | No loss of expression n = 66 | Loss of expression of all markers n = 7 | MLH1/PMS2 loss n = 16 | MSH2/MSH6 loss n = 6 | Isolated MLH1 loss n = 5 | Total n = 100 | p value |
|---|---|---|---|---|---|---|---|
Mucinous histology | |||||||
 <10% | 6(9%) | 3(43%) | 2(12.5%) | 0 | 1(20%) | 12 | 0.334 |
 10–50% | 4(6%) | 1(14%) | 1(6.25%) | 1(17%) | 0 | 7 | |
 >50% | 7(11%) | 1(14%) | 2(12.5%) | 2(33%) | 1(20%) | 13 | |
 Absent | 49(74%) | 2(29%) | 11(69%) | 3(50%) | 3(60%) | 68 | |
Signet ring differentiation | |||||||
 Present | 10(15%) | 1(14%) | 4(25%) | 0 | 1(20%) | 16 | 0.696 |
 Absent | 56(85%) | 6(86%) | 12(75%) | 6(100%) | 4(80%) | 84 | |
Poor differentiation | |||||||
 Present | 4(6%) | 1(14%) | 1(6.25%) | 2(33%) | 1(20%) | 9 | 0.188 |
 Absent | 62(94%) | 6(86%) | 15(94%) | 4(67%) | 4(80%) | 91 | |
Medullary differentiation | |||||||
 Present | 0 | 0 | 0 | 1(17%) | 0 | 1 | 0.004 |
 Absent | 65(98%) | 7(100%) | 16(100%) | 5(83%) | 5(100%) | 99 | |
Necrosis | |||||||
 Focal | 47(71%) | 4(57%) | 10(63%) | 5(83%) | 4(80%) | 70 | 0.198 |
 Widespread | 17(26%) | 1(14%) | 5(31%) | 0 | 1(20%) | 24 | |
 Absent | 2(3%) | 2(29%) | 1(6.25%) | 1(17%) | 0 | 6 | |
Tumor-infiltrating lymphocytes | |||||||
 None | 45(68%) | 2(28%) | 3(19%) | 3(50%) | 4(80%) | 57 | 0.007 |
 Mild to moderate | 15(22.7%) | 3(43%) | 6(81%) | 1(50%) | 0 | 25 | |
 Marked | 6(9%) | 2(28%) | 7(81%) | 2(50%) | 1(20%) | 18 | |
Peri-tumoral lymphocytic response | |||||||
 None | 45(68%) | 5(71%) | 11(69%) | 2(33%) | 4(80%) | 67 | 0.454 |
 Mild to moderate | 13(20%) | 1(14%) | 2(13%) | 1(17%) | 1(20%) | 18 | |
 Marked | 8(12%) | 1(14%) | 3(19%) | 3(50%) | 0 | 15 | |