Skip to main content

Table 1 Functional and pathway enrichment analysis of up-regulated and down-regulated genes in hepatocellular carcinoma (HCC) tissue

From: Identification and interaction analysis of key genes and microRNAs in hepatocellular carcinoma by bioinformatics analysis

Category Term Count % P Value
Up-regulated
 GOTERM_BP_FAT GO:0007059 ~ chromosome segregation 9 17.6 2.66E-06
 GOTERM_BP_FAT GO:0098813 ~ nuclear chromosome segregation 8 15.7 1.06E-05
 GOTERM_BP_FAT GO:0000819 ~ sister chromatid segregation 7 13.7 2.91E-05
 GOTERM_BP_FAT GO:0051301 ~ cell division 9 17.6 1.31E-04
 GOTERM_BP_FAT GO:0007067 ~ mitotic nuclear division 8 15.7 1.44E-04
 GOTERM_CC_FAT GO:0000793 ~ condensed chromosome 5 9.8 2.14E-03
 GOTERM_CC_FAT GO:0005829 ~ cytosol 18 35.3 3.98E-03
 GOTERM_CC_FAT GO:0005578 ~ proteinaceous extracellular matrix 5 9.8 1.51E-02
 GOTERM_CC_FAT GO:0098651 ~ basement membrane collagen trimer 2 3.9 2.08E-02
 GOTERM_CC_FAT GO:0005694 ~ chromosome 7 13.7 3.38E-02
 GOTERM_MF_FAT GO:0042826 ~ histone deacetylase binding 3 5.9 3.03E-02
 KEGG_PATHWAY hsa04512:ECM-receptor interaction 3 5.9 1.68E-02
Down-regulated
 GOTERM_BP_FAT GO:0006956 ~ complement activation 6 10.0 1.83E-05
 GOTERM_BP_FAT GO:0072376 ~ protein activation cascade 6 10.0 6.43E-05
 GOTERM_BP_FAT GO:0019752 ~ carboxylic acid metabolic process 12 20.0 8.21E-05
 GOTERM_BP_FAT GO:0043436 ~ oxoacid metabolic process 12 20.0 8.66E-05
 GOTERM_BP_FAT GO:0006955 ~ immune response 16 26.7 1.23E-04
 GOTERM_CC_FAT GO:0005581 ~ collagen trimer 4 6.7 7.15E-03
 GOTERM_CC_FAT GO:0072562 ~ blood microparticle 4 6.7 1.91E-02
 GOTERM_CC_FAT GO:0005579 ~ membrane attack complex 2 3.3 2.67E-02
 GOTERM_CC_FAT GO:0031988 ~ membrane-bounded vesicle 21 35.0 4.60E-02
 GOTERM_CC_FAT GO:0044421 ~ extracellular region part 22 36.7 5.00E-02
 GOTERM_MF_FAT GO:0005496 ~ steroid binding 4 6.7 3.47E-03
 GOTERM_MF_FAT GO:0070330 ~ aromatase activity 3 5.0 3.57E-03
 GOTERM_MF_FAT GO:0016712 ~ oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 3 5.0 4.11E-03
 GOTERM_MF_FAT GO:0004497 ~ monooxygenase activity 4 6.7 4.77E-03
 GOTERM_MF_FAT GO:0004252 ~ serine-type endopeptidase activity 5 8.3 7.38E-03
 KEGG_PATHWAY hsa05204:Chemical carcinogenesis 6 10.0 4.53E-05
 KEGG_PATHWAY hsa00140:Steroid hormone biosynthesis 4 6.7 3.04E-03
 KEGG_PATHWAY hsa00830:Retinol metabolism 4 6.7 4.19E-03
 KEGG_PATHWAY hsa00982:Drug metabolism - cytochrome P450 4 6.7 4.76E-03
  1. Count: the number of enriched genes in each term
  2. If there were more than five terms enriched in this category, the top five terms were selected per the P value