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Table 3 Characteristics of comorbidities (ATC code level 2, distribution and regression analyses)

From: Diabetes and beta-adrenergic blockage are risk factors for metastatic prostate cancer

ATC code level 2 Comorbidity system Distribution Positive surgical margin (R1) Lymph node metastasis (N1)
% (n/n) OR/p value OR/p value
C09 Renin angiotensin system 44.5 (202/454) 0.999/0.997 1.344/0.255
C07 Beta-blockers 32.3 (147(454) 1.929/0.020 0.953/0.878
B01 Antithrombosis 27.5 (125/454) 1.063/0.829 1.821/0.52
C10 Lipid modifiers 26.2 (110/454) 0.867/0.616 0.982/0.995
A02 Acid disorders 23.6 (107/454) 0.954/0.860 1.127/0.679
C08 Calcium channel blockers 17.2 (78/454) 0.702/0.311 0.523/0.126
C03 Diuretics 14.3 (65/454) 1.174/0.626 0.779/0.510
G04 Urologicals 12.8 (58/454) 0.653/0.232 1.346/0.387
H03 Thyroid therapy 10.1 (46/454) 1.227/0.557 1.253/0.559
A10 Diabetes 9.3 (42/454) 1.092/0.811 2.869/0.004
A07 Diarrhea, inflammation 5.1 (23/454) 0.240/0.074 0.515/0.387
N06 Psychoanaleptics 4.4 (20/454) 1.172/0.761 0.761/0.653
C01 Cardiac therapy 3.9 (18/454) 0.559/0.346 0.550/0.396
R03 Anti asthmatics 3.3 (15/454) 1.009/0.989 0.143/0.148
N05 Psycholeptics 3.1 (14/454) 1.114/0.860 2.254/0.177
C02 Antihypertensives 2.6 (12/454) 0.220/0.158 1.459/0.619
N03 Antiepileptics 1.8 (8/454) 6.048/0.051 2.824/0.306
S01 Opthalmologicals 1.5 (7/154) 2.560/0.334 0.755/0.875
A03 Functional gastroint, disorders 0.7 (3/454) 2.778/0.476 1.078/0.963
L04 Immunosuppression 0.7 (3/454) 3.537/0.361 0.0/0.999
N04 Anti parkinson drugs 0.7 (3/454) 3.956/0.276 0.0 / 0.999
A01 Stomatologic disorders 0.4 (2/454) 0.0/0.999 1.770/0.770
R01 Nasal corticoides 0.4 /2/454) 0.0/0.999 10.577/0.287
Subgroupanalysis
 Diabetes Insulin 4.2 (19/454) 1090/0.882
Metformin 7.7 (35/454) 2.989/0.009
 Beta-blockers Carvedilol 1.9 (9/454) 0.341/0.314
Metoprolol 8.9 (40/454) 2.400/0.010
Bisoprolol 14.8 (67/454) 1.202/0.533
Nebivolol 2.4 (11/454) 2.884/0.090
  1. ATC level 2: level 2 of the Anatomic Therapeutic Chemical (ATC) code describes anatomic or chemical systems within the body or in specific organs; OR odds ratio; italic = statistically significant OR