Table 3 Characteristics of comorbidities (ATC code level 2, distribution and regression analyses)
From: Diabetes and beta-adrenergic blockage are risk factors for metastatic prostate cancer
ATC code level 2 | Comorbidity system | Distribution | Positive surgical margin (R1) | Lymph node metastasis (N1) |
|---|---|---|---|---|
% (n/n) | OR/p value | OR/p value | ||
C09 | Renin angiotensin system | 44.5 (202/454) | 0.999/0.997 | 1.344/0.255 |
C07 | Beta-blockers | 32.3 (147(454) | 1.929/0.020 | 0.953/0.878 |
B01 | Antithrombosis | 27.5 (125/454) | 1.063/0.829 | 1.821/0.52 |
C10 | Lipid modifiers | 26.2 (110/454) | 0.867/0.616 | 0.982/0.995 |
A02 | Acid disorders | 23.6 (107/454) | 0.954/0.860 | 1.127/0.679 |
C08 | Calcium channel blockers | 17.2 (78/454) | 0.702/0.311 | 0.523/0.126 |
C03 | Diuretics | 14.3 (65/454) | 1.174/0.626 | 0.779/0.510 |
G04 | Urologicals | 12.8 (58/454) | 0.653/0.232 | 1.346/0.387 |
H03 | Thyroid therapy | 10.1 (46/454) | 1.227/0.557 | 1.253/0.559 |
A10 | Diabetes | 9.3 (42/454) | 1.092/0.811 | 2.869/0.004 |
A07 | Diarrhea, inflammation | 5.1 (23/454) | 0.240/0.074 | 0.515/0.387 |
N06 | Psychoanaleptics | 4.4 (20/454) | 1.172/0.761 | 0.761/0.653 |
C01 | Cardiac therapy | 3.9 (18/454) | 0.559/0.346 | 0.550/0.396 |
R03 | Anti asthmatics | 3.3 (15/454) | 1.009/0.989 | 0.143/0.148 |
N05 | Psycholeptics | 3.1 (14/454) | 1.114/0.860 | 2.254/0.177 |
C02 | Antihypertensives | 2.6 (12/454) | 0.220/0.158 | 1.459/0.619 |
N03 | Antiepileptics | 1.8 (8/454) | 6.048/0.051 | 2.824/0.306 |
S01 | Opthalmologicals | 1.5 (7/154) | 2.560/0.334 | 0.755/0.875 |
A03 | Functional gastroint, disorders | 0.7 (3/454) | 2.778/0.476 | 1.078/0.963 |
L04 | Immunosuppression | 0.7 (3/454) | 3.537/0.361 | 0.0/0.999 |
N04 | Anti parkinson drugs | 0.7 (3/454) | 3.956/0.276 | 0.0 / 0.999 |
A01 | Stomatologic disorders | 0.4 (2/454) | 0.0/0.999 | 1.770/0.770 |
R01 | Nasal corticoides | 0.4 /2/454) | 0.0/0.999 | 10.577/0.287 |
Subgroupanalysis | ||||
Diabetes | Insulin | 4.2 (19/454) | – | 1090/0.882 |
Metformin | 7.7 (35/454) | – | 2.989/0.009 | |
Beta-blockers | Carvedilol | 1.9 (9/454) | 0.341/0.314 | – |
Metoprolol | 8.9 (40/454) | 2.400/0.010 | – | |
Bisoprolol | 14.8 (67/454) | 1.202/0.533 | – | |
Nebivolol | 2.4 (11/454) | 2.884/0.090 | – | |