Table 5 Adverse events in all patients (n = 134)
Adverse event | G0 | G1 | G2 | G3 | G4 | NE | All grades (%) | Grade 3/4 (%) |
|---|---|---|---|---|---|---|---|---|
Leucocyte | 9 | 8 | 21 | 44 | 49 | 3 | 91.0 | 69.4 |
Neutrophils | 9 | 7 | 17 | 30 | 67 | 4 | 90.3 | 72.4 |
Hemoglobin | 27 | 41 | 38 | 23 | 2 | 3 | 77.6 | 18.7 |
Platelets | 55 | 21 | 18 | 24 | 13 | 3 | 56.7 | 27.6 |
AST | 87 | 38 | 3 | 3 | 0 | 3 | 32.8 | 2.2 |
ALT | 82 | 35 | 9 | 5 | 0 | 3 | 36.6 | 3.7 |
Anorexia | 52 | 59 | 15 | 2 | 0 | 6 | 56.7 | 1.5 |
Nausea | 65 | 49 | 14 | 1 | 0 | 5 | 47.8 | 0.7 |
Vomiting | 103 | 22 | 4 | 0 | 0 | 5 | 19.4 | 0.0 |
Diarrhea | 112 | 13 | 2 | 2 | 0 | 5 | 12.7 | 1.5 |
Fatigue | 50 | 59 | 15 | 6 | 0 | 4 | 59.7 | 4.5 |
Febrile neutropenia | 120 | 0 | 0 | 13 | 0 | 1 | 9.7 | 9.7 |
Fever | 97 | 22 | 12 | 1 | 0 | 2 | 26.1 | 0.7 |
Infection | 118 | 4 | 5 | 5 | 1 | 1 | 11.2 | 4.5 |
Dyspnea | 124 | 4 | 1 | 4 | 0 | 1 | 6.7 | 3.0 |
Interstitial pneumonia | 124 | 4 | 1 | 4 | 0 | 1 | 6.7 | 3.0 |
Neuropathy | 128 | 0 | 5 | 0 | 0 | 1 | 3.7 | 0.0 |
Rash | 114 | 6 | 8 | 5 | 0 | 1 | 14.2 | 3.7 |
Edema | 131 | 2 | 1 | 0 | 0 | 0 | 2.2 | 0.0 |
Mucositis | 130 | 1 | 3 | 0 | 0 | 0 | 3.0 | 0.0 |
Allergic reaction | 132 | 0 | 2 | 0 | 0 | 0 | 1.5 | 0.0 |