Table 4 Subgroup analysis stratified by different stages
From: Associations of DNMT3B −149C>T and −2437T>A polymorphisms and lung cancer risk in Chinese population
Genotype | TNM staging | |||||||
|---|---|---|---|---|---|---|---|---|
Stage I | ORa (95% CI) | Stage II | ORa (95%CI) | Stage III | ORa (95% CI) | Stage IV | ORa (95% CI) | |
−149C>T | ||||||||
TT | 23 (9.8) | 0.57 (0.32 1.78) | 4 (2.2) | 0.23 (0.29 1.57) | 12 (5.0) | 0.32 (0.31 1.58) | 4 (13.3) | 0.75 (0.31 1.28) |
CT | 78 (32.5) | 0.92 (0.54 1.52) | 41 (22.5) | 0.38 (0.42 1.81) | 68 (28.9) | 0.65 (0.38 1.85) | 10 (33.3) | 1.02 (0.82 2.54) |
CC | 138 (57.7) | Reference | 136 (75.3) | Reference | 155 (66.1) | Reference | 15 (53.3) | Reference |
CT+TT | 101 (42.3) | 1.03 (0.68 1.55) | 45 (24.7) | 0.46 (0.28 0.77) | 80 (32.9) | 0.72 (0.47 1.10) | 14 (46.6) | 1.23 (0.44 3.46) |
−2437T>A | ||||||||
AA | 20 (8.1) | 0.32 (0.28 1.35) | 21 (11.8) | 0.45 (0.28 2.51) | 20 (8.3) | 0.84 (0.81 1.95) | 4 (13.3) | 1.32 (0.82 1.69) |
TA | 91 (38.2) | 0.72 (0.82 1.96) | 66 (36.6) | 0.78 (0.84 1.92) | 101 (43.0) | 0.97 (0.58 1.92) | 15 (53.3) | 1.56 (0.78 3.51) |
TT | 128 (53.7) | Reference | 93 (51.6) | Reference | 114 (48.7) | Reference | 10 (33.3) | Reference |
TA+AA | 111 (46.3) | 0.85 (0.57 1.27) | 87 (48.4) | 0.92 (0.59 1.44) | 121 (51.3) | 1.03 (0.69 1.55) | 19 (66.6) | 1.96 (0.66 5.84) |