Prognostic significance of K-ras mutations in pancreatic cancer: a meta-analysis

Table 1 Characteristic summary of studies included in the meta-analysis

The author	Year	Country	Ethnicity	Age (years)	Gender (M/F)	Treatment	Detection method	Outcome	NOS
Allison, D.C. [16]	1998	USA	Caucasians	63 (32–80)	40/36	Operation	Enriched PCR and oligonucleotide hybridization	OS	6
Boeck, S [17]	2013	Germany	Caucasians	64 (32–78)	105/68	Chemotherapy	Pyrosequencing	OS	7
Kim, S.T. [18]	2011	Korea	Asians	≥60, n = 84 < 60, n = 52	99/37	Chemotherapy	DS	OS	7
Ogur, T [19]	2014	Japan	Asians	65 (35–84)	146/96	Chemotherapy	RT-PCR	OS	6
Schultz, N.A. [6]	2012	Denmark	Caucasians	63 (33–85)	88/82	Operation	DS	OS	7
Shin, S.H. [20]	2013	Korea	Asians	60 (22–78)	139/95	Operation	PCR-RFLP	OS	8
Sinn, B.V. [7]	2014	Germany	Caucasians	≥65, n = 81; <65, n = 72	84/69	Operation	DS	OS	7
Franko, J [21]	2008	USA	Caucasians	68 ± 12	26/24	Operation and chemotherapy	DS	OS	6
Da Cunha Santos, G [22]	2010	Canada	Caucasians	62 (40–85)	64/53	Chemotherapy	PCR and BS	OS	7
Fensterer, H [5]	2013	Germany	Caucasians	62.7	36/30	Operation and chemotherapy	High-resolution melting assay	OS	6
lkeda, N [23]	2001	Japan	Asians	63.7 (47–80)	37/11	Operation and chemotherapy	DS	OS	7
Kwon, M.J. [24]	2011	Korea	Asians	63 (45–86)	37/35	Operation and chemotherapy	RT-PCR	OS	8
Lee, J [25]	2007	Korea	Asians	≥60, n = 47; <60, n = 19	51/15	Chemotherapy	DS	OS	5
Oh, D.Y. [26]	2012	Korea	Asians	57.3 (39–77)	24/16	Chemotherapy	DS	OS	6
Salek, C [27]	2009	Czech	Caucasians	63 ± 10.5 (40–84)	28/25	Chemotherapy	GenoScan	OS	6
Kinugasa, H [28]	2015	Japan	Asians	66 (47–85)	54/21	NR	Digital PCR	OS	7
Talar-Wojnarowska, R [29]	2005	Poland	Caucasians	47–76	10/16	Operation	PCR-RFLP	OS	6

DS direct sequencing, BS bidirectional sequencing, NR not reported, RT-PCR reverse transcription polymerase chain reaction, PCR-RFLP polymerase chain reaction-restriction fragment length polymorphism, NOS Newcastle-Ottawa Scale (NOS) criteria (targeting the quality of non-randomized studies)

ISSN: 1477-7819