Table 2 Clinicopathological characteristics of stage III undifferentiated gastric adenocarcinoma in terms of histology type
Parameters | MC (n = 39) | SRCC (n = 261) | PDC (n = 581) | P value |
|---|---|---|---|---|
Age (years), mean ± SD | 64.5 ± 10.0 | 60.2 ± 13.7 | 62.7 ± 14.0 | 0.019 |
Median | 66.0 | 61.0 | 66.0 | |
Sex | 0.002 | |||
Male | 22 (56.4) | 128 (49.0) | 359 (61.8) | |
Female | 17 (43.6) | 133 (51.0) | 222 (38.2) | |
Tumor size (cm), mean ± SD | 7.6 ± 3.9 | 6.0 ± 3.7 | 5.8 ± 3.1 | 0.006 |
Median | 7.0 | 5.0 | 5.0 | |
Type of gastrectomy | 0.696 | |||
Total | 13 (33.3) | 96 (36.8) | 226 (38.9) | |
Subtotal | 26 (66.7) | 165 (63.2) | 355 (61.1) | |
Extent of LN dissection | 0.268 | |||
<D2 | 13 (33.3) | 71 (27.2) | 190 (32.7) | |
≥D2 | 26 (66.7) | 190 (72.8) | 391 (67.3) | |
No. of LN retrieval, mean ± SD | 29.2 ± 16.3 | 30.2 ± 16.2 | 28.6 ± 14.9 | 0.373 |
Median | 25.0 | 27.0 | 26.0 | |
T status | 0.627 | |||
T2 | 2 (5.1) | 6 (2.3) | 10 (1.7) | |
T3 | 1 (2.6) | 5 (1.9) | 9 (1.5) | |
T4 | 36 (92.3) | 250 (95.8) | 562 (96.8) | |
LN status | ||||
N0 | 2 (5.1) | 1 (0.4) | 13 (2.2) | 0.118 |
N1 | 8 (20.5) | 41 (15.7) | 86 (14.8) | |
N2 | 11 (28.2) | 52 (19.9) | 136 (23.4) | |
N3 | 18 (46.2) | 167 (64.0) | 346 (59.6) | |
Positive margins (R1 resection) | 8 (20.5) | 48 (18.4) | 84 (14.5) | 0.255 |
Lymphatic invasiona | 0.442 | |||
No | 8 (21.1) | 35 (13.5) | 88 (15.4) | |
Yes | 30 (78.9) | 225 (86.5) | 484 (84.6) | |
Vascular invasiona | 0.767 | |||
No | 30 (78.9) | 204 (79.1) | 439 (76.9) | |
Yes | 8 (21.1) | 54 (20.9) | 132 (23.1) | |
Perineural invasiona | 0.003 | |||
No | 17 (45.9) | 57 (22.2) | 175 (30.8) | |
Yes | 20 (54.1) | 200 (77.8) | 394 (69.2) | |
Complicationsb | 8 (20.5) | 44 (16.9) | 101 (17.4) | 0.854 |
Surgery-related | 8 (20.5) | 35 (13.4) | 71 (12.2) | 0.316 |
Leakage | 4 (10.3) | 19 (7.3) | 34 (5.9) | |
Intra-abdominal abscess | 4 (10.3) | 12 (4.6) | 28 (4.8) | |
Wound infection | 1 (2.6) | 4 (1.5) | 15 (2.6) | |
Bleeding | 1 (2.6) | 8 (3.1) | 9 (1.5) | |
Delayed gastric emptying | 0 | 1 (0.4) | 4 (0.7) | |
Others | 0 | 3 (1.1) | 3 (0.5) | |
Surgery unrelated | 1 (2.6) | 16 (6.1) | 48 (8.3) | 0.275 |
Pneumonia | 0 | 2 (0.8) | 12 (2.1) | |
Cardiovascular event | 0 | 5 (1.9) | 6 (1.0) | |
Sepsis | 0 | 2 (0.8) | 7 (1.2) | |
Paralytic ileus | 0 | 1 (0.4) | 4 (0.7) | |
Atelectasis | 0 | 0 | 5 (0.9) | |
Others | 1 (2.6) | 18 (6.9) | 38 (6.5) | |
Hospital mortality | 2 (5.1) | 13 (5.0) | 32 (5.5) | 0.950 |
Chemotherapy | 30 (76.9) | 205 (78.5) | 423 (72.8) | 0.197 |