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Table 6 Univariate and multivariate analyses of potential risk factors for distant metastasis in patients with invasive cancer (n = 272)

From: Comparison of ipsilateral breast tumor recurrence after breast-conserving surgery between ductal carcinoma in situ and invasive breast cancer

Variables Univariate Multivariate
HR (95 % CI) p value HR (95 % CI) p value
Age <40 years 1.5 (0.4–5.7) 0.51 1.2 (0.3–4.2) 0.78
T stage, T2 (vs. T1) 1 0.83 1 0.98
Positive LN 4.8 (1.3–17.7) 0.02* 3.4 (0.9–12.3) 0.04*
Stage, IIB–IIIA 3.1 (1.1–8.4) 0.03* 3.83 (1.4–10.8) 0.07
IBTR 11.5 (3.9–33.4) <0.001* 14.4 (4.8–43.1) <0.001*
Positive margin status 1 0.99 1 0.95
Omission of Radiotherapy 1 0.99 1 0.90
Negative ER 1.6 (0.5–4.4) 0.39 2.7 (0.1–10.6) 0.25
Negative PR 1.8 (0.6–4.9) 0.22 1.8 (0.7–4.8) 0.90
Positive HER2 1.2 (0.2–8.4) 0.92 1 0.98
Positive LVI 1.2 (1.0–10.1) 0.84 1 0.99
Positive Ki-67 1.1 (0.4–2.9) 0.87 1.2 (0.4–3.0) 0.65
High histologic grade 1 0.833 1 0.98
  1. *p < 0.05