Sentinel node biopsy during thoracolaparoscopic esophagectomy for advanced esophageal cancer

Table 2 Overview of the literature on SN mapping with a radioactive tracer in esophageal cancer (including the results of the current feasibility study)

Author	Number	Histology	Tracer	Scint	Time of scint	Probe	DR overall	DR probe	Accuracy	FN Rate	Sensitivity
Arima [15]	19	SCC	99mTc Sn	No	n.a.	Intra + ex vivo	n.a.	95 %	78 %	22 %	78 %
Bohanes [25]	1	SCC	99mTc nano	Yes	Directly after injection	Intra	n.a.	n.a.	n.a.	n.a.	n.a.
Burian [26]	20	AC	99mTc colloid + dye	?	n.a.	?	85 %	?	?	?	?
Fujii [23]a	61	?	99mTc Sn	Yes	?	Intra	92 %	?	92 %	14 %	?
Kato [16]	25	SCC	99mTc ReS	Yes	+/− 12 h after injection	Intra	92 %	?	91.3 %	8.7 %	86.7 %
Kitagawa 2000 [14]a	16	?	99mTc Sn	Yes	?	Intra	88 %	?	93 %	?	89 %
Kitagawa 2001 [24]a	33	?	99mTc Sn	?	?	Intra	?	?	?	?	85 %
Kosugi [17]	10	?	99mTc Sn	Yes	3 h after injection	Ex vivo	60 %	90 %	77.8 %	100 %	0 %
Lamb [27]	57	AC	99mTc nano	No	n.a.	Intra + ex vivo	n.a.	100 %	96 %	4 %	?
Tanaka [18]	1	SCC	99mTc Sn	Yes	3 h after injection	No	n.a.	n.a.	n.a.	n.a.	n.a.
Yasuda [19]	23	?	99mTc Sn	No	n.a.	Intra	?	?	?	?	?
Current study	8	AC + SCC	99mTc nano	Yes	1 hr and 3 hrs after injection	Intra + ex vivo	88 %; 100 %	38 %	38 %	100 %	0 %

Legend
AC adenocarcinoma, ReS rhenium sulfide, Colloid colloid (unspecified), SCC squamous cell carcinoma, DR detection rate, Scint scintigraphy, FN false negative, Sn tin, Intra intraoperatively, Tc technetium, n.a. not applicable, ? not reported, nano nanocolloid
^aThese three reports are from the same research group and describe the results of the same, but enlarged, study population

ISSN: 1477-7819