Table 5 Univariate and multivariate analyses of prognostic factors for overall survival according to the period of adjuvant chemotherapy
Factors (OS) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
p value | p value | Hazard ratio | 95 % CI | |
Age | ||||
<65 vs. >65 years | .154 | .094 | 0.663 | 0.410–1.073 |
Sex | ||||
Male vs. female | .596 | .302 | 0.757 | 0.447–1.284 |
Depth of tumor invasion | ||||
t1, 2 vs. t3, 4 | <.001 | .014 | 5.176 | 1.390–19.269 |
Lymph node metastasis | ||||
n0, 1 vs. n2, 3 | <.001 | .019 | 4.819 | 1.288–18.022 |
Histological type (WHO) | ||||
Undifferentiated vs. differentiated | .348 | .703 | 0.547 | 0.362–1.985 |
Lauren classification | ||||
Diffuse vs. intestinal | .170 | .556 | 1.271 | 0.572–2.825 |
Stage | ||||
II vs. III | <.001 | .851 | 1.142 | 0.286–4.559 |
Period of adjuvant chemotherapy | ||||
<6 months | .182 | .374 | 0.877 | 0.476–1.616 |
6~12 months | .721 | .267 | 0.655 | 0.310–1.383 |
12~24 months | .076 | .005 | 0.347 | 0.167–0.726 |
>24 months | .127 | .061 | 0.358 | 0.123–1.047 |