Table 1 Characteristics of 162 smoking patients with locally advanced stage IV head and neck squamous cell carcinoma receiving induction chemotherapy with TPF

Age

Median

53

Mean

52.4

Range

31–72

Sex

Male

156 (96 %)

Female

6 (4 %)

Primary tumor site

Hypopharynx

19 (12 %)

Larynx

17 (10 %)

Oropharynx

60 (37 %)

Oral cavity

62 (38 %)

Unknown primary

4 (3 %)

Clinical T classification

T1

4 (3 %)

T2

23 (14 %)

T3

12 (7 %)

T4a

49 (30 %)

T4b

70 (43 %)

Tx

4 (3 %)

Clinical N classification

N0

28 (18 %)

N1

20 (12 %)

N2a

7 (4 %)

N2b

49 (30 %)

N2c

41 (25 %)

N3

17 (11 %)

Clinical 7th AJCC stage

IVA

80 (49 %)

IVB

82 (51 %)

Alcohol

Absent

16 (10 %)

Present

146 (90 %)

Betel nut chewing

Absent

31 (19 %)

Present

131 (81 %)

p16 expression

Negative

128 (79 %)

Positive

3 (2 %)

Unknown

31 (19 %)

Response to induction chemotherapy

Complete response

9 (6 %)

Partial response

90 (55 %)

Stable disease

42 (26 %)

Progression disease

21 (13 %)