Table 1 The characteristics of the pooled studies
From: Prognostic value of microRNA-21 in pancreatic ductal adenocarcinoma: a meta-analysis
Study | Year | Country | Ethnicity | Sample size | Stage | Results | Survival analysis | HR (95Â % CI) for prognostic outcomes | Adjuvant chemotherapy |
|---|---|---|---|---|---|---|---|---|---|
Dillhoff | 2008 | USA | Caucasian | 80 | NR | OS | KM | OS, 4.08 (1.98, 8.38), P = 0.037 | NR |
Giovannetti a | 2010 | Italy | Caucasian | 28 | I–III | OS, DFS | U | OS, 3.1 (1.4–7.3), P = 0.008 | Y |
DFS, 4.4 (1.8–10.7), P = 0.001 | |||||||||
Giovannetti b | 2010 | Italy | Caucasian | 31 | IV | OS, PFS | U | OS, 3.1 (1.4–7.1), P = 0.01 | Y |
PFS, 2.4 (1.1–5.3), P = 0.03 | |||||||||
Hwang | 2010 | Korea | Asian | 82 | II–IV | OS, DFS | M | OS, 2.26 (1.34, 3.80), P = 0.002 | Y |
DFS, 2.793 (1.466–5.319), P = 0.002 | |||||||||
Jamieson | 2012 | UK | Caucasian | 48 | II–IV | OS | M | OS, 3.22 (1.21–8.58), P = 0.019 | Y |
Liu | 2012 | China | Asian | 38 | I–IV | OS | KM | OS, 2.89 (1.22–6.81), P = 0.02 | NR |
Nagao | 2012 | Japan | Asian | 65 | I–IV | OS | U | OS, 2.32 (1.19–4.52), P = 0.045 | NR |
Wang | 2013 | China | Asian | 177 | III–IV | OS | M | OS, 1.71 (1.15–2.54), P = 0.008 | Y |
Kadera | 2013 | USA | Caucasian | 145 | I–IV | OS | U | OS, 1.1 (0.7–1.6), P = 0.7 | NR |
Papaconstantinou | 2013 | Greece | Caucasian | 88 | I–IV | OS | M | OS, 1.72 (1.25–12.3), P = 0.019 | NR |
Ma | 2013 | China | Asian | 78 | I–IV | OS | M | OS, 2.60 (1.15–5.87), P = 0.021 | NR |
Dhayat | 2015 | Germany | Caucasian | 91 | II | OS, RFS | M | OS, 3.06 (1.37–6.85), P = 0.0064 | Y |
RFS, 2.25 (1.06–4.77), P = 0.0338 | |||||||||
Khan | 2015 | UK | Caucasian | 12 | IV | OS, PFS | KM | OS, 1.46 (0.41–5.21), P = 0.564 | Y |
PFS, 4.7 (1.1–19.7), P = 0.032 |