Clinical, radiological, and pathological features of 33 adult unilateral thalamic gliomas

Zhang, Peng; Wang, Xingchao; Ji, Nan; Xie, Jian; Han, Jinsong; Ren, Xiaohui; Song, Guidong; Wu, Ruofei; Zhang, Liwei; Gao, Zhixian

doi:10.1186/s12957-016-0820-x

World Journal of Surgical Oncology

Table 5 Parameters correlated with PFS and/or OS in 30 adult UTGs

From: Clinical, radiological, and pathological features of 33 adult unilateral thalamic gliomas

Characteristics	Median PFS (INR)^a	Progression-free survival rates (%)				P value	Median OS (INR)^a	Overall survival rates (%)				P value
Characteristics	Median PFS (INR)^a	6 months	12 months	18 months	24 months	P value	Median OS (INR)^a	6 months	12 months	18 months	24 months	P value
Age (years)
<42	N/A	87.5	62.5	25.0	6.3	<0.001	N/A	100.0	93.8	56.3	18.8	<0.001
≥42	N/A	64.3	50.0	28.6	14.3	<0.001	N/A	71.4	64.3	35.7	35.7	<0.001
Sex
Male	N/A	78.9	47.4	31.6	10.5	0.037	N/A	94.7	84.2	57.9	36.8	<0.001
Female	N/A	72.7	72.7	18.2	9.1	0.037	N/A	72.7	72.7	27.3	9.1	<0.001
Lateral
Left	N/A	84.6	69.2	30.8	15.4	<0.001	N/A	92.3	92.3	46.2	38.5	<0.001
Right	N/A	70.6	47.1	23.5	5.9	<0.001	N/A	82.4	70.6	47.1	17.6	<0.001
Preoperative kps
≥60	N/A	85.7	66.7	33.3	14.3	<0.001	N/A	95.2	90.5	52.3	23.8	<0.001
<60	9(3–20)	55.6	33.3	11.1	0.0	<0.001	N/A	66.7	55.6	33.3	33.3	<0.001
Postoperative kps
≥60	N/A	84.0	72.0	36.0	16.0	<0.001	N/A	92.0	84.0	52.0	40.0	<0.001
<60	N/A	40.0	20.0	0.0	0.0	<0.001	N/A	60.0	60.0	20.0	20.0	<0.001
Symptom duration (months)
≥2	N/A	93.3	73.3	40.0	20.0	<0.001	N/A	93.3	93.3	66.7	46.7	<0.001
<2	11(2–24)	60.0	40.0	13.3	0.0	<0.001	N/A	80.0	66.7	26.7	6.7	<0.001
Cystic changes
Yes	N/A	85.7	71.4	42.9	28.6	<0.001	N/A	100.0	100.0	85.7	57.1	<0.001
No	N/A	73.9	52.2	21.7	4.3	<0.001	N/A	82.6	73.9	34.8	17.4	<0.001
Diameter (cm)
<3.9	N/A	91.7	66.7	41.7	16.7	<0.001	N/A	91.7	91.7	50.0	33.3	<0.001
≥3.9	N/A	66.7	50.0	16.7	5.5	<0.001	N/A	83.3	72.2	44.4	22.2	<0.001
Pathology
Low grade	N/A	100.0	100.0	50.0	25.0	<0.001	N/A	100.0	100.0	75.0	50.0	<0.001
High grade	N/A	68.2	40.9	18.2	4.5	<0.001	N/A	81.8	72.7	36.4	18.2	<0.001
Postoperative v-p shunt
Yes	14.5(12–24)	100.0	75.0	25.0	0.0	–	N/A	100.0	100.0	50.0	25.0	<0.001
No	N/A	73.1	53.8	26.9	11.5	–	N/A	84.6	76.9	46.2	26.9	<0.001
Resection
Gtr	N/A	82.4	64.7	35.3	17.6	<0.001	N/A	88.2	76.5	52.9	35.3	<0.001
Str/pr	12(2–20)	69.2	46.2	15.4	0.0	<0.001	N/A	84.6	84.6	38.5	15.4	<0.001

N/A not available
^aMedian PFS and median OS was calculated based on the final status of follow-up
^bMeans no correlation in univariate analysis

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