Fig. 2From: IDH mutations may not preclude distant, trans-tentorial spread in gliomas: a case report and review of the literatureHistopathological features of the initial tumor. a A routine H&E stain demonstrated hypercellularity, nuclear atypia, and mitotic figures suggestive of anaplastic astrocytoma. b Immunohistochemical staining showed positivity for the IDH1 (R132H) mutation. c MIB-1 immunohistochemical staining showed a mitotic index of approximately 5Â %Back to article page