Skip to main content

Table 2 Prognostic factors of overall survival and disease-free survival

From: Hepatic resection provided long-term survival for patients with intermediate and advanced-stage resectable hepatocellular carcinoma

  OS DFS
Analysis OR 95 % CI p value OR 95 % CI p value
Univariate
 Male sex 1.092 0.741–1.609 0.653 0.975 0.716–1.328 0.873
 Age >60 years 0.848 0.633–1.135 0.263 0.934 0.737–1.185 0.572
 ECOG (0/1/2) 0.681 0.426–1.112 0.752 0.704 0.421–1.191 0.726
 Child-Pugh A/B 3.123 0.995–9.800 0.099 1.780 0.570–5.560 0.364
 HBV (+) 1.050 0.754–1.463 0.772 1.140 0.863–1.505 0.350
 HCV (+) 1.142 0.695–1.876 0.608 1.174 0.773–1.782 0.462
 AST >40 U/L 1.592 1.209–2.096 0.001 1.528 1.217–1.919 <0.001
 ALT >40 U/L 1.142 0.866–1.506 0.348 1.192 0.949–1.496 0.133
 TBIL >17.5 μmol/L 0.789 0.584–1.066 0.117 0.854 0.671–1.086 0.194
 ALB ≤35 g/L 1.154 0.628–2.119 0.651 1.422 0.859–2.353 0.239
 PT >14 s 2.012 1.064–3.803 0.052 2.191 0.780–3.753 0.401
 AFP >400 ng/mL 1.516 1.118–2.057 0.009 1.434 1.113–1.847 0.007
 Liver cirrhosis (+) 0.890 0.658–1.204 0.450 1.030 0.798–1.329 0.821
 Tumor size >5 cm 2.925 2.212–3.867 <0.001 1.904 1.518–2.388 <0.001
 Microscopic portal vein (+) 2.281 1.714–3.035 <0.001 1.825 1.432–2.325 <0.001
 Macroscopic vascular invasion (+) 2.819 1.963–4.048 <0.001 2.228 1.616–3.082 <0.001
 Multiple nodes but ≤3 2.818 1.975–4.058 <0.001 2.486 1.823–3.390 <0.001
 Blood loss >1000 mL 1.649 1.049–2.591 0.042 1.032 0.618–1.641 0.327
 Blood transfusion (+) 3.310 2.402–4.561 <0.001 1.229 0.712–1.548 0.614
 Complications (+) 1.254 0.937–1.679 0.133 1.439 1.130–1.832 0.003
 Major liver resection 2.475 1.854–3.258 <0.001 1.941 1.528–2.465 <0.001
 Adjuvant TAC/TACE 1.132 0.683–2.126 0.627 0.134 0.512–1.168 0.079
Multivariate
 AST >40 U/L 1.044 0.722–1.510 0.818 0.860 0.611–1.209 0.385
 AFP >400 ng/mL 1.523 1.107–2.095 0.010 1.213 0.922–1.598 0.168
 Tumor size >5 cm 2.002 1.443–2.778 <0.001 1.489 1.129–2.078 0.013
 Microscopic portal vein (+) 1.559 1.126–2.159 0.007 1.266 0.967–1.657 0.086
 Macroscopic vascular invasion (+) 1.655 1.096–2.499 0.017 0.982 0.672–1.435 0.926
 Multiple nodes but ≤3 2.134 1.460–3.120 <0.001 0.888 0.636–1.239 0.484
 Blood loss >1000 mL 1.142 0.708–1.842 0.585 1.073 0.696–1.654 0.749
 Blood transfusion 1.025 0.686–1.531 0.904 1.238 0.945–1.621 0.121
 Major liver resection 1.348 0.964–1.887 0.081 1.100 0.836–1.449 0.495
 Complications     1.136 0.877–1.472 0.333