Table 2 Pathological findings of ASPS of the uterus corpus
Authors and years | Macroscopic findings | Microscopic findings | Immunohistochemical findings | Electron microscopy |
|---|---|---|---|---|
Gray et al. (1986) [27] | Uncapsulated, circumscribed intramyometrial nodule, 0.4Â cm | Large cell, arranged in organoid appearance separated by delicate fibrovascular stroma | ND | Membrane bound crystalline granule inclusions in the cytoplasm |
Nolan and Gaffney (1990) [28] | Mass of 7Â cm, bulging into endometrial cavity | Large cells with granular and vacuolated cytoplasms, organoid arrangement, separated by fibrovascular septae. PASDR crystals | ND | Intracytoplasmic crystalline inclusions |
Guillou et al. (1991) [4] | 3 × 2.5 × 2.5 cm well-circumscribed intramyometrial nodule | Uncapsulated lesion pushing border delineated by endometrium, large cells with organoid arrangement, separated by fibrovascular septae, granular cytoplasms with crystals. Areas with nuclear pleomorphism | POS Vim, focal POS HMB45, NKI/C3, patchy dot-like cytokeratin lw POS | ND |
Burch et al. (1994) [29] | 3-cm endometrial polyp | Large cells with granular cytoplasm, crystals on PAS D | ND | Intracytoplasmic crystalline inclusions |
Nielsen et al. (1995) [30] | 1-cm intramural nodule | Large cell, arranged in organoid appearance separated by delicate fibrovascular stroma crystals on PAS D | ND | ND |
| Â | 3.5-cm submucosal nodule | Large cell, arranged in organoid appearance separated by delicate fibrovascular stroma, crystals on PAS D | ND | ND |
Radig K et al. (1998) [31] | 3-cm well-circumscribed yellow-whitish, intramural nodule | Pseudoalveolar and trabecular pattern, polygonal and round cells vesicular nuclei, with nucleoli, crystals on PAS D | NEG for S100, Ck, EMA, POS caldes | Intracytoplasmic crystalline inclusions |
4.5-cm well-circumscribed, intramural nodule | Pseudoalveolar pattern, granular | ND | Intracytoplasmic crystalline inclusions absent | |
Kasashima S et al. (2007) [5] | 1.9 × 1.9 × 1.0 cm greyish, endometrial exophytic nodule | Large cells with organoid arrangement, separated by fibrovascular septae, granular cytoplasms with crystals | Nuclear POS: TFE3, PGR, ER, CD10 | ND |
Vesicular nuclei and pleomorphic nuclei and multinucleated cells. Mitoses very rare. No M Lym | NEG: Vim, caldes, Sma, Myo, HMB45, S100, EMA, Chrom, Syn, Myoge, Myogl | |||
Zhang et al. (2012) [32] | 2.4 × 2.0 × 1.8 cm yellow-whitish exophytic tumour, sub-endometrium of the lower uterine segment | Large cells with organoid arrangement, separated by delicate fibrovascular septae, granular cytoplasms with crystals M lymph | NEG: Ae1/AE3, EMA, Sma, Des, S-100, CD10, Synapt, Chrom | ND |
Ki67: 5Â % diffuse POS Nuclear TFE3 | ||||
Present case | 5-cm intramural nodule, well-circumscribed, with irregular border , soft yellow, brownish and grey, with a large haemorrhagic zone centrally located | Solid “non-organoid” pattern, abundant eosinophilic granular cytoplasm, with distinct border, and vesicular nuclei and prominent nucleolus | Focal POS to Sma, desm, Caldes and diffuse and strong nuclear POS to TFE3 NEG: Ae1/AE3, EMA, Sma, Des, S-100, CD10, NSE, Synapt, Chrom, inh, MiTF | Intracytoplasmic crystalline inclusions |
Areas with spindle elements with nuclear, pleomorphism, hyperchromasia, nuclear cytoplasmic pseudo-inclusions and multinucleations | Diffuse POS nuclear TFE3 |