Study | Number of patients | M/F | Age | Sources of tumor (N) | Volume of MPE (N) | Quality of life | Pleural perfusion (N) | Group 1/2 (N) | End point |
---|---|---|---|---|---|---|---|---|---|
Yunfang et al. [15] | 168 | NA | 38–85 | Lung/pleura (102) | NA | KPS | P + M versus P | 84/84 | RR, DCR, SI, AEs |
Breast (32) | |||||||||
Digestive tract (34) | |||||||||
Sijie et al. [13] | 153 | 68/85 | 32–84 | Lung/pleura (117) | Large (57) | KPS | IL-11 + P + M versus IL-11 + P | 75/78 | RR, DCR, SI, AEs |
Breast (26) | Moderate (82) | ||||||||
Lymphoma (10) | Small (14) | ||||||||
Zenmin et al. [9] | 110 | NA | 35–83 | Lung/pleura (61) | NA | KPS | P + M versus P | 56/54 | RR, DCR, SI, AEs |
Breast (32) | |||||||||
Digestive tract (17) | |||||||||
Daiju and Xiaodong [19] | 150 | 96/54 | 45-75 | Lung/pleura (150) | NA | KPS | IL-2 + M versus IL-2 | 75/75 | RR, DCR, SI, AEs |
а-IFN + M versus a-IFN | |||||||||
Zhiwen et al. [12] | 90 | 47/43 | 40–77 | Lung (90) | NA | KPS | CP + M versus CP | 45/45 | RR, DCR, SI, AEs |
Liangfa et al. [11] | 98 | 56/42 | 48–73 | Lung/pleura (58) | Large (57) | KPS | P + M versus P | 50/48 | RR, DCR, SI, AEs |
Breast (24) | Moderate (23) | ||||||||
Digestive tract (6) | Small (18) | ||||||||
Lymphoma (7) | |||||||||
Others (3) | |||||||||
Xiaowei et al. [10] | 120 | 67/53 | 49–76 | Lung/pleura (49) | NA | KPS | MMC + M versus MMC | 60/60 | RR, DCR, SI, AEs |
Breast (19) | |||||||||
Digestive tract (32) | |||||||||
Lymphoma (8) | |||||||||
Others (12) | |||||||||
Guoan [18] | 86 | 54/32 | 65-81 | Lung(86) | NA | KPS | BLM + M versus BLM | 44/42 | RR, DCR, SI, AEs |
Li [8] | 80 | 46/34 | 20–82 | Lung/pleura (29) | Large (48) | KPS | P + M versus P | 40/40 | RR, DCR, SI, AEs |
Breast (14) | Moderate (32) | ||||||||
Digestive tract (21) | |||||||||
Lymphoma (7) | |||||||||
Others (2) | |||||||||
Ziqiang [14] | 90 | 57/33 | 31–75 | Lung/pleura (43) | NA | KPS | IL-2 + M versus IL-2 + P | 45/45 | RR, DCR, SI, AEs |
Breast (20) | |||||||||
Digestive tract (18) | |||||||||
Others (9) | |||||||||
Yushun and Jie [16] | 93 | 63/30 | NA | Lung/pleura (93) | NA | KPS | P + M versus P | 47/46 | RR, DCR, SI, AEs |
Zhenfeng et al. [17] | 82 | 50/36 | 60–82 | Lung (82) | NA | KPS | HCPT + M versus HCPT | 42/40 | RR, DCR, SI, AEs |