Table 3 Influence of interaction between living habits and genetic polymorphisms on the risk of CRC
From: Genetic polymorphisms in XRCC1 genes and colorectal cancer susceptibility
Factor 1 | Factor 2 | Controls (%) | Cases (%) | χ 2 value | OR | 95 % CI |
|---|---|---|---|---|---|---|
Total smoking amount | Arg194Trp | |||||
Never smoking | Trp/Trp | 25 (7.14) | 13 (4.06) | 1 | – | – |
Slight smoking | Arg/Trp + Arg/Arg | 77 (22.0) | 56 (17.5) | 0.765 | 1.40 | 0.66–2.97 |
Heavy smoking | Arg/Trp + Arg/Arg | 47 (13.4) | 71 (22.2) | 7.794 | 2.91 | 1.35–6.24 |
Total smoking amount | Arg280His | |||||
Never smoking | Arg/Arg | 160 (45.7) | 116 (36.3) | 1 | – | – |
Slight smoking | Arg/His + His/His | 28 (8.00) | 22 (6.88) | 0.067 | 1.08 | 0.59–1.99 |
Heavy smoking | Arg/His + His/His | 15 (4.29) | 18 (5.63) | 1.880 | 1.66 | 0.80–3.42 |
Total smoking amount | Arg399Gln | |||||
Never smoking | Arg/Arg | 130 (37.1) | 81 (25.3) | 1 | – | – |
Slight smoking | Arg/Gln + Gln/Gln | 37 (10.6) | 30 (9.38) | 0.865 | 1.30 | 0.75–2.27 |
Heavy smoking | Arg/Gln + Gln/Gln | 23 (6.57) | 39 (12.2) | 11.69 | 2.72 | 1.52–4.89 |
Drinking habit | Arg194Trp | |||||
No | Trp/Trp | 32 (9.14) | 19 (5.94) | 1 | – | – |
Yes | Arg/Trp + Arg/Arg | 56 (16.0) | 64 (20.0) | 3.704 | 1.93 | 0.98–3.77 |
Drinking habit | Arg280His | |||||
No | Arg/Arg | 213 (60.9) | 173 (54.1) | 1 | – | – |
Yes | Arg/His + His/His | 21 (6.00) | 28 (8.75) | 2.657 | 1.64 | 0.90–2.99 |
Drinking habit | Arg399Gln | |||||
No | Arg/Arg | 166 (47.4) | 108 (33.8) | 1 | – | – |
Yes | Arg/Gln + Gln/Gln | 21 (6.00) | 27 (8.44) | 4.754 | 1.98 | 1.06–3.67 |