The prognostic significance of a postoperative systemic inflammatory response in patients with colorectal cancer

Table 5 The correlations between the overall survival and various clinicopathological factors

	Univariate analysis			Multivariate analysis
	Hazard ratio	95 % CI	p value	Hazard ratio	95 % CI	p value
Age (>70 years)	2.113	1.142–3.911	0.017	0.912	0.204–4.083	0.904
Gender (Male)	0.684	0.361–1.295	0.243
Location of primary tumor (Colon)	0.749	0.404-1.389	0.360
Tumor depth (T4)	1.863	1.007–3.448	0.048	4.592	0.896–23.544	0.068
Histological type (Poorly, mucinous)	3.449	1.582–7.518	0.002	0	0	0.988
Lymphatic involvement (Positive)	2.744	0.839–8.979	0.095
Venous involvement (Positive)	2.102	1.080–4.093	0.029	0.350	0.068–1.800	0.209
Number of lymph node metastases	2.924	1.816–4.707	<0.001	14.677	2.571–83.779	0.003
Preoperative CEA (>5 ng/ml)	1.939	0.875–4.299	0.103
Preoperative CA19-9 (>37 U/ml)	1.298	0.176–9.586	0.798
Adjuvant chemotherapy (Yes)	0.332	0.080–1.384	0.130
Chemotherapy regimen (with oxaliplatin)	0.726	0.216–2.433	0.603
Postoperative NLR (>3.0)	3.597	1.643–7.875	0.001	15.713	1.590–155.227	0.018
Postoperative GPS (≥1)	1.982	0.933–4.208	0.075
Preoperative NLR (>2.5)	2.204	1.023–4.750	0.044	6.599	0.928–46.914	0.059
Preoperative GPS (≥1)	2.723	1.372–5.404	0.004	7.238	1.180–44.415	0.032

CEA carcinoembryonic antigen, CA19-9 carbohydrate antigen 19-9, NLR neutrophil-to-lymphocyte ratio, CRP C-reactive protein, GPS Glasgow prognostic score

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