Metastatic liver disease from non-colorectal, non-neuroendocrine, non-sarcoma cancers: a systematic review

Table 2 Prognostic factors

Prognostic factor	Variables that influence overall survival	Variables that influence progression-free survival
Sex	39	35
Preoperative treatment of liver	15
Metastatic situation: synchronous/metachronous	17, 23, 27, 34, 38	44
Primary site and histological subtype	15–26, 33, 34, 37–41, 43	31, 35
Symptomatic at the time of resection	41^a
Hepatic involvement	25, 26
Type of the intervention performed	17, 37, 39–41
Macroscopically incomplete resection (R2)	17, 19, 38, 40	29
Surgical margin status	16, 17, 19, 32, 34, 37, 38, 40, 42	35
Adjuvant treatment	15, 17, 18, 20, 21, 24–26, 37	44
Presence of extrahepatic disease	15, 16, 20, 27, 28, 30, 37
Surgery timing	19, 22, 26, 31	31
Postoperative complications	17, 44	44
Number of metastases	17, 19, 26, 27, 33, 39, 44	44
Size of metastases	26, 29, 36, 41, 42	29, 44
Presence of vascular invasion	36
Lymph node metastases	29, 36, 39	29
Disease-free survival	26, 30, 37, 38, 41	17, 31, 35, 44
Blood transfusion	44	44

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